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  3. VEGFB

VEGFB (Vascular endothelial growth factor B)

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The Function of VEGFB

Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.

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Protein names

Recommended name:

Vascular endothelial growth factor B

Short name:

VRF

Alternative name(s):

VEGF-B
VEGF-related factor

Top Gene-Substance Interactions

Substances That Increase VEGFB

Substances Interaction Organism Category

Substances That Decrease VEGFB

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • NF-kappaB1

Tissue specificity:

Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.

Gene Pathways:

  • Pathways in cancer
  • Signal Transduction
  • Cytokine-cytokine receptor interaction
  • Hemostasis
  • Pancreatic cancer
  • Bladder cancer
  • mTOR signaling pathway
  • Renal cell carcinoma
  • Rheumatoid arthritis

Molecular Function:

  • Chemoattractant Activity
  • Growth Factor Activity
  • Heparin Binding
  • Vascular Endothelial Growth Factor Receptor 1 Binding

Biological Processes:

  • Angiogenesis
  • Cardiac Muscle Contraction
  • Coronary Vasculature Development
  • Induction Of Positive Chemotaxis
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Gene Expression
  • Negative Regulation Of Neuron Apoptotic Process
  • Platelet Degranulation
  • Positive Regulation Of Cell Division
  • Positive Regulation Of Endothelial Cell Proliferation
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Mast Cell Chemotaxis
  • Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
  • Positive Regulation Of Protein Kinase B Signaling
  • Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
  • Positive Regulation Of Vascular Wound Healing
  • Protein O-Linked Glycosylation
  • Response To Hypoxia
  • Vascular Endothelial Growth Factor Receptor Signaling Pathway

Drug Bank:

  • Aflibercept
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| D623_10030656| GW7_20680| H920_10315| I79_019743| M91_13010| PAL_GLEAN10011430| PANDA_004854| vascular endothelial growth factor B isoform VEGFB-167| VEGF-B| VEGFL| VEGF-related factor| VRF| vegfb

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