The Function of VEGFB
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
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Protein names
Recommended name:
Vascular endothelial growth factor BShort name:
VRFAlternative name(s):
VEGF-BVEGF-related factor
Top Gene-Substance Interactions
Substances That Increase VEGFB
| Substances | Interaction | Organism | Category |
Substances That Decrease VEGFB
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
Gene Pathways:
Molecular Function:
- Growth Factor Activity
- Heparin Binding
- Chemoattractant Activity
- Vascular Endothelial Growth Factor Receptor 1 Binding
Biological Processes:
- Angiogenesis
- Response To Hypoxia
- Positive Regulation Of Endothelial Cell Proliferation
- Platelet Degranulation
- Protein O-Linked Glycosylation
- Negative Regulation Of Gene Expression
- Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Vascular Wound Healing
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Neuron Apoptotic Process
- Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Induction Of Positive Chemotaxis
- Positive Regulation Of Cell Division
- Positive Regulation Of Protein Kinase B Signaling
- Cardiac Muscle Contraction
- Positive Regulation Of Mast Cell Chemotaxis
- Coronary Vasculature Development
- Positive Regulation Of Erk1 And Erk2 Cascade
Drug Bank:
- Aflibercept