The Function of VANGL2
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear.
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Protein names
Recommended name:
Vang-like protein 2Alternative name(s):
Loop-tail protein 1 homologStrabismus 1
Van Gogh-like protein 2
Top Gene-Substance Interactions
VANGL2 Interacts with These Diseases
| Disease | Score |
Substances That Increase VANGL2
| Substances | Interaction | Organism | Category |
Substances That Decrease VANGL2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Biological Processes:
- Establishment Of Planar Polarity
- Neural Tube Closure
- Hair Follicle Development
- Heart Looping
- Membranous Septum Morphogenesis
- Muscular Septum Morphogenesis
- Planar Cell Polarity Pathway Involved In Axis Elongation
- Rho Protein Signal Transduction
- Anterior/Posterior Pattern Specification
- Heparan Sulfate Proteoglycan Biosynthetic Process
- Convergent Extension Involved In Neural Plate Elongation
- Regulation Of Wnt Signaling Pathway
- Glomerulus Development
- Regulation Of Actin Cytoskeleton Organization
- Somatic Stem Cell Population Maintenance
- Cell Migration Involved In Kidney Development
- Post-Anal Tail Morphogenesis
- Dopaminergic Neuron Axon Guidance
- Serotonergic Neuron Axon Guidance
- Wound Healing
- Positive Regulation Of Jun Kinase Activity
- Apical Protein Localization
- Establishment Or Maintenance Of Epithelial Cell Apical/Basal Polarity
- Somatic Stem Cell Division
- Establishment Of Body Hair Planar Orientation
- Digestive Tract Morphogenesis
- Convergent Extension Involved In Axis Elongation
- Inner Ear Receptor Stereocilium Organization
- Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis
- Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis
- Lateral Sprouting Involved In Lung Morphogenesis
- Kidney Morphogenesis
- Planar Cell Polarity Pathway Involved In Heart Morphogenesis
- Cochlea Morphogenesis
- Establishment Of Planar Polarity Involved In Neural Tube Closure
- Planar Cell Polarity Pathway Involved In Neural Tube Closure
- Planar Cell Polarity Pathway Involved In Axon Guidance
- Non-Motile Cilium Assembly