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  3. VANGL2

VANGL2 (VANGL planar cell polarity protein 2)

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The Function of VANGL2

Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear.

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Protein names

Recommended name:

Vang-like protein 2

Alternative name(s):

Loop-tail protein 1 homolog
Strabismus 1
Van Gogh-like protein 2

Top Gene-Substance Interactions

VANGL2 Interacts with These Diseases

Disease Score

Substances That Increase VANGL2

Substances Interaction Organism Category

Substances That Decrease VANGL2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • HOXA3
  • STAT5A
  • E47
  • c-Myb
  • NF-kappaB2
  • RelA

Gene Pathways:

  • Signal Transduction
  • Wnt signaling pathway

Biological Processes:

  • Anterior/Posterior Pattern Specification
  • Apical Protein Localization
  • Cell Migration Involved In Kidney Development
  • Cochlea Morphogenesis
  • Convergent Extension Involved In Axis Elongation
  • Convergent Extension Involved In Neural Plate Elongation
  • Digestive Tract Morphogenesis
  • Dopaminergic Neuron Axon Guidance
  • Establishment Of Body Hair Planar Orientation
  • Establishment Of Planar Polarity
  • Establishment Of Planar Polarity Involved In Neural Tube Closure
  • Establishment Or Maintenance Of Epithelial Cell Apical/Basal Polarity
  • Glomerulus Development
  • Hair Follicle Development
  • Heart Looping
  • Heparan Sulfate Proteoglycan Biosynthetic Process
  • Inner Ear Receptor Stereocilium Organization
  • Kidney Morphogenesis
  • Lateral Sprouting Involved In Lung Morphogenesis
  • Membranous Septum Morphogenesis
  • Muscular Septum Morphogenesis
  • Neural Tube Closure
  • Non-Motile Cilium Assembly
  • Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis
  • Planar Cell Polarity Pathway Involved In Axis Elongation
  • Planar Cell Polarity Pathway Involved In Axon Guidance
  • Planar Cell Polarity Pathway Involved In Heart Morphogenesis
  • Planar Cell Polarity Pathway Involved In Neural Tube Closure
  • Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis
  • Positive Regulation Of Jun Kinase Activity
  • Post-Anal Tail Morphogenesis
  • Regulation Of Actin Cytoskeleton Organization
  • Regulation Of Wnt Signaling Pathway
  • Rho Protein Signal Transduction
  • Serotonergic Neuron Axon Guidance
  • Somatic Stem Cell Division
  • Somatic Stem Cell Population Maintenance
  • Wound Healing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_01884| CB1_000141008| EGK_01506| GW7_00521| H920_20479| loop-tail| loop tail associated protein| loop-tail-associated protein| loop-tail protein 1| loop-tail protein 1 homolog| Lootl| Lp| Lpp1| ltap| M959_02752| MDA_GLEAN10006589| N300_14269| N302_08315| N308_06342| N325_07903| N333_06669| PAL_GLEAN10006986| protein strabismus| protein trilobite| ska17| ska<m17Jus>| stb1| STBM| stbm1| Strabismus| strabismus 1| TREES_T100018299| tri| trilobite| vang| Vang1l2| vangl2-a| vangl2-b| vang-like 2| Vang-like 2-A| vang-like 2 (van gogh, Drosophila)| vang-like protein| vang-like protein 2| Vang-like protein 2-A| Van Gogh| van Gogh-like protein 2| Y1Q_031681| Z169_15700| vangl2

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