The Function of VANGL2
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear.
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Protein names
Recommended name:
Vang-like protein 2Alternative name(s):
Loop-tail protein 1 homologStrabismus 1
Van Gogh-like protein 2
Top Gene-Substance Interactions
VANGL2 Interacts with These Diseases
| Disease | Score |
Substances That Increase VANGL2
| Substances | Interaction | Organism | Category |
Substances That Decrease VANGL2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Biological Processes:
- Anterior/Posterior Pattern Specification
- Apical Protein Localization
- Cell Migration Involved In Kidney Development
- Cochlea Morphogenesis
- Convergent Extension Involved In Axis Elongation
- Convergent Extension Involved In Neural Plate Elongation
- Digestive Tract Morphogenesis
- Dopaminergic Neuron Axon Guidance
- Establishment Of Body Hair Planar Orientation
- Establishment Of Planar Polarity
- Establishment Of Planar Polarity Involved In Neural Tube Closure
- Establishment Or Maintenance Of Epithelial Cell Apical/Basal Polarity
- Glomerulus Development
- Hair Follicle Development
- Heart Looping
- Heparan Sulfate Proteoglycan Biosynthetic Process
- Inner Ear Receptor Stereocilium Organization
- Kidney Morphogenesis
- Lateral Sprouting Involved In Lung Morphogenesis
- Membranous Septum Morphogenesis
- Muscular Septum Morphogenesis
- Neural Tube Closure
- Non-Motile Cilium Assembly
- Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis
- Planar Cell Polarity Pathway Involved In Axis Elongation
- Planar Cell Polarity Pathway Involved In Axon Guidance
- Planar Cell Polarity Pathway Involved In Heart Morphogenesis
- Planar Cell Polarity Pathway Involved In Neural Tube Closure
- Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis
- Positive Regulation Of Jun Kinase Activity
- Post-Anal Tail Morphogenesis
- Regulation Of Actin Cytoskeleton Organization
- Regulation Of Wnt Signaling Pathway
- Rho Protein Signal Transduction
- Serotonergic Neuron Axon Guidance
- Somatic Stem Cell Division
- Somatic Stem Cell Population Maintenance
- Wound Healing