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  3. VAMP8

VAMP8 (Vesicle associated membrane protein 8)

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The Function of VAMP8

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes.

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Protein names

Recommended name:

Vesicle-associated membrane protein 8

Short name:

EDB

Alternative name(s):

VAMP-8
Endobrevin

VAMP8 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1010 (VAMP8) ??
  2. RS10187424 (VAMP8) ??
  3. RS3731827 (VAMP8) ??

Top Gene-Substance Interactions

VAMP8 Interacts with These Diseases

Disease Score

Substances That Increase VAMP8

Substances Interaction Organism Category

Substances That Decrease VAMP8

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • CUTL1
  • C/EBPalpha
  • FOXO1a
  • GATA-1
  • FOXO1
  • GATA-3

Tissue specificity:

Platelets.

Gene Pathways:

  • Membrane Trafficking
  • SNARE interactions in vesicular transport

Molecular Function:

  • Chloride Channel Inhibitor Activity
  • Snap Receptor Activity
  • Snare Binding

Biological Processes:

  • Autophagosome Maturation
  • Mucus Secretion
  • Negative Regulation Of Secretion By Cell
  • Positive Regulation Of Histamine Secretion By Mast Cell
  • Post-Golgi Vesicle-Mediated Transport
  • Protein Transport
  • Regulation Of Protein Localization To Plasma Membrane
  • Vesicle Fusion
  • Viral Entry Into Host Cell
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CB1_000688073| D623_10011335| edb| endobrevin| GW7_11287| H920_05976| M91_17786| M959_04988| MDA_GLEAN10011862| N300_05468| N302_02063| PAL_GLEAN10005179| PANDA_011947| TREES_T100005354| VAMP-8| vesicle-associated membrane protein 8| vesicle-associated membrane protein 8 (endobrevin)| vesicle-associated membrane protein 8-like protein| Y1Q_016827| vamp8

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