The Function of VAMP8
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes.
Protein names
Recommended name:
Vesicle-associated membrane protein 8Short name:
EDBAlternative name(s):
VAMP-8Endobrevin
- RS1010 (VAMP8) ??
- RS10187424 (VAMP8) ??
- RS3731827 (VAMP8) ??
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Top Gene-Substance Interactions
VAMP8 Interacts with These Diseases
| Disease | Score |
Substances That Increase VAMP8
| Substances | Interaction | Organism | Category |
Substances That Decrease VAMP8
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Platelets.
Gene Pathways:
Molecular Function:
Biological Processes:
- Autophagosome Maturation
- Mucus Secretion
- Negative Regulation Of Secretion By Cell
- Positive Regulation Of Histamine Secretion By Mast Cell
- Post-Golgi Vesicle-Mediated Transport
- Protein Transport
- Regulation Of Protein Localization To Plasma Membrane
- Vesicle Fusion
- Viral Entry Into Host Cell