The Function of USP2
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1.
Protein names
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 2Alternative name(s):
41 kDa ubiquitin-specific proteaseDeubiquitinating enzyme 2
Ubiquitin thioesterase 2
Ubiquitin-specific-processing protease 2
- RS2195525 (USP2) ??
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Top Gene-Substance Interactions
Substances That Increase USP2
| Substances | Interaction | Organism | Category |
Substances That Decrease USP2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level).
Induction:
Down-regulated by cisplatin (at protein level).
Enzyme Regulation:
Cleavage is inhibited by ubiquitin in a dosage-dependent manner. Cleavage is blocked by ubiquitin aldehyde.
Cofactor:
Binds 1 zinc ion.
Molecular Function:
- Cyclin Binding
- Cysteine-Type Endopeptidase Activity
- Metal Ion Binding
- Thiol-Dependent Ubiquitin-Specific Protease Activity
- Ubiquitin Protein Ligase Binding
Biological Processes:
- Cell Cycle
- Circadian Behavior
- Circadian Regulation Of Gene Expression
- Entrainment Of Circadian Clock By Photoperiod
- Locomotor Rhythm
- Muscle Organ Development
- Negative Regulation Of Skeletal Muscle Tissue Development
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Mitotic Cell Cycle
- Positive Regulation Of Skeletal Muscle Tissue Development
- Protein Deubiquitination
- Protein Stabilization
- Ubiquitin-Dependent Protein Catabolic Process