Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

Upstream stimulatory factor 1 (USF1). USF1 is a transcription factor, which affects the expression of other genes. In particular, USF1 affects the production of proteins involved in keeping energy levels stable [R]. 

The effects of USF1 are complex - decreased levels may protect against cardiovascular disease, but may also increase the chance of cancer (see below for more information) USF1 SNPs are associated with heart disease in females [R],  increased triglycerides, and familial combined hyperlipidemia (FCHL) [R]. 

These SNPs (eg. rs2073658) probably change the activity of USF1 in response to insulin [R]. USF1 increases transforming growth factor B1 (TGFB1), thrombospondin 1 (TSP1), and osteopontin [R]. 

Decreased USF1: In clinical trials, reduced levels of USF1 improved insulin sensitivity and reduced atherosclerosis [R]. USF1 is important for the activity of the p53 protein, which is a key tumor-suppressor. Thus a reduction in USF1 levels could initiate tumor formation [R]. Decreased levels of USF1 are associated with oral cancer [R]. Reduced activity of USF1 was associated with breast tumors [R].

     From NCBI Gene: Hyperlipidemia, combined, 1From UniProt: Hyperlipidemia combined 1 (HYPLIP1): A disorder characterized by a variable pattern of elevated levels of serum total cholesterol, triglycerides or both. It is observed in a percentage of individuals with premature coronary heart disease. [MIM:602491]

     From NCBI Gene: This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013] From UniProt: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• Sp1
• GATA-1
• SREBP-1a
• SREBP-1b
• LyF-1
• USF1
• Ik-1
• USF-1

Molecular Function:

• Double-Stranded Dna Binding
• Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
• Enzyme Binding
• Protein Kinase Binding
• Protein Homodimerization Activity
• Histone Deacetylase Binding
• Bhlh Transcription Factor Binding
• Sequence-Specific Dna Binding
• Protein Heterodimerization Activity

Biological Processes:

• Regulation Of Transcription From Rna Polymerase Ii Promoter By Glucose
• Positive Regulation Of Transcription From Rna Polymerase Ii Promoter By Glucose
• Response To Hypoxia
• Glucose Metabolic Process
• Regulation Of Transcription From Rna Polymerase Ii Promoter
• Transcription From Rna Polymerase Ii Promoter
• Response To Uv
• Late Viral Transcription
• Cellular Response To Insulin Stimulus
• Glucose Homeostasis
• Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
• Carbon Catabolite Regulation Of Transcription
• Negative Regulation Of Fibrinolysis
• Lipid Homeostasis

*synonyms