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  3. USF1

USF1 (Upstream transcription factor 1)

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Summary of USF1

USF1 is a transcription factor, which affects the expression of other genes. In particular, USF1 affects the production of proteins involved in keeping energy levels stable [R].

The effects of USF1 are complex - decreased levels may protect against cardiovascular disease, but may also increase the chance of cancer (see below for more information) USF1 SNPs are associated with heart disease in females [R],  increased triglycerides, and familial combined hyperlipidemia (FCHL) [R]. 

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The Function of USF1

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

Protein names

Recommended name:

Upstream stimulatory factor 1

Alternative name(s):

Class B basic helix-loop-helix protein 11
bHLHb11
Major late transcription factor 1

USF1 SNPs

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  1. RS2073658 (USF1) ??
  2. RS2516839 (USF1) ??
  3. RS2774276 (USF1) ??

Top Gene-Substance Interactions

Substances That Increase USF1

Substances Interaction Organism Category

Substances That Decrease USF1

Substances Interaction Organism Category

Advanced Summary

Upstream stimulatory factor 1 (USF1). USF1 is a transcription factor, which affects the expression of other genes. In particular, USF1 affects the production of proteins involved in keeping energy levels stable [R]. 

The effects of USF1 are complex - decreased levels may protect against cardiovascular disease, but may also increase the chance of cancer (see below for more information) USF1 SNPs are associated with heart disease in females [R],  increased triglycerides, and familial combined hyperlipidemia (FCHL) [R]. 

These SNPs (eg. rs2073658) probably change the activity of USF1 in response to insulin [R]. USF1 increases transforming growth factor B1 (TGFB1), thrombospondin 1 (TSP1), and osteopontin [R]. 

Decreased USF1: In clinical trials, reduced levels of USF1 improved insulin sensitivity and reduced atherosclerosis [R]. USF1 is important for the activity of the p53 protein, which is a key tumor-suppressor. Thus a reduction in USF1 levels could initiate tumor formation [R]. Decreased levels of USF1 are associated with oral cancer [R]. Reduced activity of USF1 was associated with breast tumors [R].

     From NCBI Gene: Hyperlipidemia, combined, 1From UniProt: Hyperlipidemia combined 1 (HYPLIP1): A disorder characterized by a variable pattern of elevated levels of serum total cholesterol, triglycerides or both. It is observed in a percentage of individuals with premature coronary heart disease. [MIM:602491]

     From NCBI Gene: This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013] From UniProt: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Sp1
  • GATA-1
  • SREBP-1a
  • SREBP-1b
  • LyF-1
  • USF1
  • Ik-1
  • USF-1

Molecular Function:

  • Bhlh Transcription Factor Binding
  • Double-Stranded Dna Binding
  • Enzyme Binding
  • Histone Deacetylase Binding
  • Protein Heterodimerization Activity
  • Protein Homodimerization Activity
  • Protein Kinase Binding
  • Sequence-Specific Dna Binding
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding

Biological Processes:

  • Carbon Catabolite Regulation Of Transcription
  • Cellular Response To Insulin Stimulus
  • Glucose Homeostasis
  • Glucose Metabolic Process
  • Late Viral Transcription
  • Lipid Homeostasis
  • Negative Regulation Of Fibrinolysis
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter By Glucose
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Transcription From Rna Polymerase Ii Promoter By Glucose
  • Response To Hypoxia
  • Response To Uv
  • Transcription From Rna Polymerase Ii Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| bHLHb11| class B basic helix-loop-helix protein 11| D623_10024244| FCHL| fchl1| H920_20467| helix-loop-helix protein Usf| HYPLIP1| M91_20751| major late transcription factor 1| MDA_GLEAN10002444| mltf| mltfi| N303_01175| N308_07947| PAL_GLEAN10017957| PANDA_018845| rUSF1a| SpF1| uef| upstream stimulatory factor| upstream stimulatory factor 1| upstream stimulatory factor 1a| Upstream stimulatory factor 1 (Major late transcription factor 1)| USF| UY3_00360| Y1Q_011959| Y956_03212| usf1

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