Summary of USF1
USF1 is a transcription factor, which affects the expression of other genes. In particular, USF1 affects the production of proteins involved in keeping energy levels stable [R].
The effects of USF1 are complex - decreased levels may protect against cardiovascular disease, but may also increase the chance of cancer (see below for more information) USF1 SNPs are associated with heart disease in females [R], increased triglycerides, and familial combined hyperlipidemia (FCHL) [R].
The Function of USF1
Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
Protein names
Recommended name:
Upstream stimulatory factor 1Alternative name(s):
Class B basic helix-loop-helix protein 11bHLHb11
Major late transcription factor 1
- RS2073658 (USF1) ??
- RS2516839 (USF1) ??
- RS2774276 (USF1) ??
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Top Gene-Substance Interactions
Substances That Increase USF1
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Substances That Decrease USF1
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Advanced Summary
Upstream stimulatory factor 1 (USF1). USF1 is a transcription factor, which affects the expression of other genes. In particular, USF1 affects the production of proteins involved in keeping energy levels stable [R].
The effects of USF1 are complex - decreased levels may protect against cardiovascular disease, but may also increase the chance of cancer (see below for more information) USF1 SNPs are associated with heart disease in females [R], increased triglycerides, and familial combined hyperlipidemia (FCHL) [R].
These SNPs (eg. rs2073658) probably change the activity of USF1 in response to insulin [R]. USF1 increases transforming growth factor B1 (TGFB1), thrombospondin 1 (TSP1), and osteopontin [R].
Decreased USF1: In clinical trials, reduced levels of USF1 improved insulin sensitivity and reduced atherosclerosis [R]. USF1 is important for the activity of the p53 protein, which is a key tumor-suppressor. Thus a reduction in USF1 levels could initiate tumor formation [R]. Decreased levels of USF1 are associated with oral cancer [R]. Reduced activity of USF1 was associated with breast tumors [R].
From NCBI Gene: Hyperlipidemia, combined, 1From UniProt: Hyperlipidemia combined 1 (HYPLIP1): A disorder characterized by a variable pattern of elevated levels of serum total cholesterol, triglycerides or both. It is observed in a percentage of individuals with premature coronary heart disease. [MIM:602491]
From NCBI Gene: This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013] From UniProt: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Bhlh Transcription Factor Binding
- Double-Stranded Dna Binding
- Enzyme Binding
- Histone Deacetylase Binding
- Protein Heterodimerization Activity
- Protein Homodimerization Activity
- Protein Kinase Binding
- Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
Biological Processes:
- Carbon Catabolite Regulation Of Transcription
- Cellular Response To Insulin Stimulus
- Glucose Homeostasis
- Glucose Metabolic Process
- Late Viral Transcription
- Lipid Homeostasis
- Negative Regulation Of Fibrinolysis
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter By Glucose
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Transcription From Rna Polymerase Ii Promoter By Glucose
- Response To Hypoxia
- Response To Uv
- Transcription From Rna Polymerase Ii Promoter