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UQCRC2 (Ubiquinol-cytochrome c reductase core protein II)

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The Function of UQCRC2

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.

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Protein names

Recommended name:

Cytochrome b-c1 complex subunit 2, mitochondrial

Alternative name(s):

Complex III subunit 2
Core protein II
Ubiquinol-cytochrome-c reductase complex core protein 2

Top Gene-Substance Interactions

UQCRC2 Interacts with These Diseases

Disease Score

Substances That Increase UQCRC2

Substances Interaction Organism Category

Substances That Decrease UQCRC2

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: mitochondrial complex III deficiencyFrom NCBI Gene: Mitochondrial complex III deficiency, nuclear type 5From UniProt: Mitochondrial complex III deficiency, nuclear 5 (MC3DN5): A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. [MIM:615160]

     From NCBI Gene: The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015] From UniProt: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • HNF-1A
  • HNF-1
  • Bach1
  • AREB6
  • Pax-5
  • FOXC1
  • c-Myb

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Alzheimer's disease
  • Cardiac muscle contraction
  • Huntington's disease
  • Oxidative phosphorylation
  • Parkinson's disease

Caution:

Does not seem to have a protease activity as it lack the zinc-binding site.

Molecular Function:

  • Metalloendopeptidase Activity
  • Zinc Ion Binding

Biological Processes:

  • Aerobic Respiration
  • Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
  • Oxidative Phosphorylation
  • Protein Processing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| complex III subunit 2| core protein II| cytochrome bc-1 complex core protein II| cytochrome b-c1 complex subunit 2, mitochondrial| MC3DN5| NOL11| Nucleolar protein 11| OXPHOS complex III core protein 2| QCR2| ubiquinol-cytochrome-c reductase complex core protein 2| ubiquinol-cytochrome C reductase complex core protein 2, mitochondrial precursor (Complex III subunit II)| ubiquinol cytochrome c reductase core protein 2| UQCR2| uqcrc2

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