The Function of UQCRC2
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.
Protein names
Recommended name:
Cytochrome b-c1 complex subunit 2, mitochondrialAlternative name(s):
Complex III subunit 2Core protein II
Ubiquinol-cytochrome-c reductase complex core protein 2
Top Gene-Substance Interactions
UQCRC2 Interacts with These Diseases
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Substances That Increase UQCRC2
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Substances That Decrease UQCRC2
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Advanced Summary
Covered on Genetics Home Reference: mitochondrial complex III deficiencyFrom NCBI Gene: Mitochondrial complex III deficiency, nuclear type 5From UniProt: Mitochondrial complex III deficiency, nuclear 5 (MC3DN5): A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. [MIM:615160]
From NCBI Gene: The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015] From UniProt: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Caution:
Does not seem to have a protease activity as it lack the zinc-binding site.
Molecular Function:
Biological Processes:
- Aerobic Respiration
- Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
- Oxidative Phosphorylation
- Protein Processing