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  3. ULK2

ULK2 (Unc-51 like autophagy activating kinase 2)

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The Function of ULK2

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.

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Protein names

Recommended name:

Serine/threonine-protein kinase ULK2

Alternative name(s):

Unc-51-like kinase 2

ULK2 SNPs

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  1. RS397969 (ULK2) ??

Top Gene-Substance Interactions

Substances That Increase ULK2

Substances Interaction Organism Category

Substances That Decrease ULK2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • MEF-2A
  • XBP-1
  • USF1
  • USF-1

Gene Pathways:

  • Regulation of autophagy
  • mTOR signaling pathway

Molecular Function:

  • Atp Binding
  • Protein Serine/Threonine Kinase Activity

Biological Processes:

  • Autophagy
  • Axon Extension
  • Negative Regulation Of Collateral Sprouting
  • Protein Autophosphorylation
  • Regulation Of Autophagy
  • Response To Starvation
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Serine/threonine-protein kinase ULK2| A306_15819| AS27_13485| AS28_08302| ATG1B| CB1_000529001| GW7_02166| H920_09887| I79_001738| M91_01725| M959_13509| N300_11181| N301_15403| N302_07727| N303_12447| N305_15161| N306_12083| N307_07316| N308_07045| N310_05639| N312_07931| N320_02060| N321_06405| N322_08827| N324_01610| N325_08270| N326_05319| N327_08078| N328_10408| N330_11285| N331_12028| N332_03558| N333_09656| N334_08894| N335_14426| N336_10680| N339_11538| N340_00264| N341_08242| serine/threonine-protein kinase Unc51.2| TREES_T100007800| Unc51.2| unc-51 like kinase 2| unc-51-like kinase 2| UY3_05038| Y1Q_010766| Y956_11570| Z169_00856| ulk2

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