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  3. UHRF1

UHRF1 (Ubiquitin like with PHD and ring finger domains 1)

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The Function of UHRF1

Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.

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Protein names

Recommended name:

E3 ubiquitin-protein ligase UHRF1

Alternative name(s):

Inverted CCAAT box-binding protein of 90 kDa
Nuclear protein 95
Nuclear zinc finger protein Np95
HuNp95
hNp95
RING finger protein 106
Transcription factor ICBP90
Ubiquitin-like PHD and RING finger domain-containing protein 1
hUHRF1
Ubiquitin-like-containing PHD and RING finger domains protein 1

UHRF1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS34232444 (UHRF1) ??

Top Gene-Substance Interactions

Substances That Increase UHRF1

Substances Interaction Organism Category

Substances That Decrease UHRF1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • E2F-1

Tissue specificity:

Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.

Induction:

Up-regulated in proliferating cells, and down-regulated in quiescent cells. Down-regulated upon adriamycin-induced DNA damage, in a p53/TP53 and CDKN1A-dependent way. Induced by E2F1 transcription factor.

Developmental stage:

Expressed in fetal thymus, liver and kidney.

Molecular Function:

  • Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Hemi-Methylated Dna-Binding
  • Histone Binding
  • Identical Protein Binding
  • Ligase Activity
  • Methylated Histone Binding
  • Methyl-Cpg Binding
  • Nucleosomal Histone Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Ubiquitin Protein Ligase Activity
  • Ubiquitin-Protein Transferase Activity
  • Zinc Ion Binding

Biological Processes:

  • Cell Cycle
  • Cell Proliferation
  • Dna Repair
  • Histone Monoubiquitination
  • Histone Ubiquitination
  • Maintenance Of Dna Methylation
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Cellular Protein Metabolic Process
  • Positive Regulation Of Dna Topoisomerase (Atp-Hydrolyzing) Activity
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Protein Autoubiquitination
  • Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
  • Regulation Of Methylation-Dependent Chromatin Silencing
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Ac2-121| AL022808| AS27_10912| AS28_12294| CB1_000320058| D623_10010562| E3 ubiquitin-protein ligase UHRF1| fb97f09| GB16860| GW7_20499| H920_09761| hNP95| hUHRF1| huNp95| ICBP90| inverted CCAAT box-binding protein of 90 kDa| liver regeneration-related protein LRRG126| M91_17101| M959_00867| MDA_GLEAN10011086| mUhrf1| N300_07767| N301_07258| N305_00645| N309_09110| N310_01297| N311_05367| N312_09427| N321_03480| N322_07138| N324_09339| N326_05067| N328_07776| N329_00649| N332_02462| N333_07356| N334_08336| N335_12223| N336_08490| N339_09872| N340_09976| Np95| nuclear phosphoprotein 95| nuclear protein 95| nuclear zinc finger protein Np95| PAL_GLEAN10006083| PANDA_019595| RING finger protein 106| RNF106| TDRD22| transcription factor ICBP90| ubiquitin-like, containing PHD and RING finger domains, 1| Ubiquitin-like-containing PHD and RING finger domains protein 1| Ubiquitin-like PHD and RING finger domain-containing protein 1| ubiquitin-like, PHD and RING finger domains containing protein| ubiquitin-like with PHD and ring finger domains 1| ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase| UHRF2| UY3_18854| Y1Q_008130| Y956_14230| Z169_09737| uhrf1

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