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  3. UGT2B15

UGT2B15 (UDP glucuronosyltransferase family 2 member B15)

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The Function of UGT2B15

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.

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Protein names

Recommended name:

UDP-glucuronosyltransferase 2B15

Short name:

HLUG4

Alternative name(s):

UDPGT 2B15
UDP-glucuronosyltransferase 2B8
UDPGT 2B8
UDPGTh-3

UGT2B15 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS115219551 (UGT2B15) ??
  2. RS115765562 (UGT2B15) ??
  3. RS141360540 (UGT2B15) ??
  4. RS1902023 (UGT2B15) ??
  5. RS293428 (UGT2B15) ??

Top Gene-Substance Interactions

UGT2B15 Interacts with These Diseases

Disease Score

Substances That Increase UGT2B15

Substances Interaction Organism Category

Substances That Decrease UGT2B15

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • PPAR-gamma1
  • CUTL1
  • PPAR-gamma2
  • HOXA3
  • C/EBPalpha
  • MRF-2
  • ARP-1
  • AREB6
  • Gfi-1

Tissue specificity:

Expressed in many tissues. Present in liver, prostate and testis.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Steroid hormone biosynthesis
  • Metabolism of xenobiotics by cytochrome P450
  • Retinol metabolism
  • Drug metabolism - cytochrome P450
  • Ascorbate and aldarate metabolism
  • Drug metabolism - other enzymes
  • Other types of O-glycan biosynthesis
  • Pentose and glucuronate interconversions
  • Porphyrin and chlorophyll metabolism
  • Starch and sucrose metabolism

Caution:

PubMed:2116769 thought that this was a separate form (UGT2B8). The name UGT2B8 has now been reused for a rat enzyme.

Molecular Function:

  • Glucuronosyltransferase Activity

Biological Processes:

  • Cellular Glucuronidation
  • Flavonoid Biosynthetic Process
  • Flavonoid Glucuronidation
  • Steroid Metabolic Process
  • Xenobiotic Metabolic Process

Drug Bank:

  • Dabigatran Etexilate
  • Ezetimibe
  • Morphine
  • Oxazepam
  • Valproic Acid
  • Acetaminophen
  • Lorazepam
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

HLUG4| UDP-glucuronosyltransferase 2B15| UDP-glucuronosyltransferase 2B43| UDP-glucuronosyltransferase 2B8| UDP glucuronosyltransferase 2 family, member 15| UDP glucuronosyltransferase 2 family, member B8| UDP glucuronosyltransferase 2 family, polypeptide B15| UDP-glucuronosyltransferase UGT2B15| UDP-glucuronyltransferase, family 2, beta-15| UDP glycosyltransferase 2B15| UDPGT2B15| UDPGT 2B8| UDPGTH3| UDP gycosyltransferase 2 family, member B15| UGT2B43| UGT2B8| uridine diphosphate glucuronosyltransferase 2 family, member B8| uridine diphosphate glycosyltransferase 2 family, member B15| ugt2b15

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