The Function of UGT2B15
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
Protein names
Recommended name:
UDP-glucuronosyltransferase 2B15Short name:
HLUG4Alternative name(s):
UDPGT 2B15UDP-glucuronosyltransferase 2B8
UDPGT 2B8
UDPGTh-3
- RS115219551 (UGT2B15) ??
- RS115765562 (UGT2B15) ??
- RS141360540 (UGT2B15) ??
- RS1902023 (UGT2B15) ??
- RS293428 (UGT2B15) ??
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Top Gene-Substance Interactions
UGT2B15 Interacts with These Diseases
| Disease | Score |
Substances That Increase UGT2B15
| Substances | Interaction | Organism | Category |
Substances That Decrease UGT2B15
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in many tissues. Present in liver, prostate and testis.
Gene Pathways:
- Metabolic pathways
- Metabolism
- Steroid hormone biosynthesis
- Metabolism of xenobiotics by cytochrome P450
- Retinol metabolism
- Drug metabolism - cytochrome P450
- Ascorbate and aldarate metabolism
- Drug metabolism - other enzymes
- Other types of O-glycan biosynthesis
- Pentose and glucuronate interconversions
- Porphyrin and chlorophyll metabolism
- Starch and sucrose metabolism
Caution:
PubMed:2116769 thought that this was a separate form (UGT2B8). The name UGT2B8 has now been reused for a rat enzyme.
Molecular Function:
Biological Processes:
- Cellular Glucuronidation
- Flavonoid Biosynthetic Process
- Flavonoid Glucuronidation
- Steroid Metabolic Process
- Xenobiotic Metabolic Process
Drug Bank:
- Dabigatran Etexilate
- Ezetimibe
- Morphine
- Oxazepam
- Valproic Acid
- Acetaminophen
- Lorazepam