Summary of UCP3
The Function of UCP3
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
Protein names
Recommended name:
Mitochondrial uncoupling protein 3Short name:
UCP 3Alternative name(s):
Solute carrier family 25 member 9- RS1726745 (UCP3) ??
- RS1800006 (UCP3) ??
- RS1800849 (UCP3) ??
- RS2075577 (UCP3) ??
- RS2229707 (UCP3) ??
- RS3781907 (UCP3) ??
- RS647126 (UCP3) ??
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Top Gene-Substance Interactions
UCP3 Interacts with These Diseases
| Disease | Score |
Fixes
Mice without PPAR alpha have 20X less UCP-3 (R).
How to Increase PPAR alpha:
- Cold (R),
- Exercise (R),
- Fasting (R) (R).
- Zinc (R)
- Fish oil/DHA (R),
- R-Lipoic Acid (R),
- Hydroxytyrosol (R),
- Resveratrol (R),
- Cinnamon (R),
- Epimedium/Icariin (R, R2),
- Nicotinamide Riboside/Niagen NAD+ (R).
- Oregano -carvacrol (R), Biochanin A (R)
- Carnitine (R),
- Naringenin (R)
- PQQ (R),
- Genistein (R),
- Palmitoylethanolamide (R)
- Lion's Mane (R)
Substances That Increase UCP3
| Substances | Interaction | Organism | Category |
Substances That Decrease UCP3
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: ObesityFrom UniProt: Obesity (OBESITY): A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. [MIM:601665]
From NCBI Gene: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008] From UniProt: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.
Gene Pathways:
Molecular Function:
- Oxidative Phosphorylation Uncoupler Activity
- Transporter Activity
- Structural Constituent Of Ribosome
Biological Processes:
- Aging
- Cellular Response To Hormone Stimulus
- Fatty Acid Metabolic Process
- Lipid Metabolic Process
- Mitochondrial Transport
- Proton Transport
- Respiratory Gaseous Exchange
- Response To Cold
- Response To Glucocorticoid
- Response To Hypoxia
- Response To Insulin
- Response To Nutrient
- Response To Superoxide
- Translation