UCP3 | SelfDecode | Genome Analysis

Summary of UCP3

The UCP3 gene encodes uncoupling protein 3. This protein sits on the mitochondrial membrane and is part of energy metabolism processes [R].

UCP3 helps keep your body at the right temperature. It signals for energy to be “burned” as heat rather than stored for use in cells. This process sounds inefficient, but it keeps you warm when it’s cold [R].

Variants in the UCP3 gene have been linked to [R, R]:

High cholesterol
High blood sugar
Obesity
Metabolic syndrome

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Mitochondrial uncoupling protein 3

Short name:

UCP 3

Alternative name(s):

Solute carrier family 25 member 9

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RS1726745 (UCP3) ??
RS1800006 (UCP3) ??
RS1800849 (UCP3) ??
RS2075577 (UCP3) ??
RS2229707 (UCP3) ??
RS3781907 (UCP3) ??
RS647126 (UCP3) ??

Top Gene-Substance Interactions

UCP3 Interacts with These Diseases

Disease	Score

Fixes

Mice without PPAR alpha have 20X less UCP-3 (R).

How to Increase PPAR alpha:

Cold (R),
Exercise (R),
Fasting (R) (R).
Zinc (R)
Fish oil/DHA (R),
R-Lipoic Acid (R),
Hydroxytyrosol (R),
Resveratrol (R),
Cinnamon (R),
Epimedium/Icariin (R, R2),
Nicotinamide Riboside/Niagen NAD+ (R).
Oregano -carvacrol (R), Biochanin A (R)
Carnitine (R),
Naringenin (R)
PQQ (R),
Genistein (R),
Palmitoylethanolamide (R)
Lion's Mane (R)

Substances That Increase UCP3

Category:

Substances	Interaction	Organism	Category

Substances That Decrease UCP3

Category:

Substances	Interaction	Organism	Category

Advanced Summary

From NCBI Gene: ObesityFrom UniProt: Obesity (OBESITY): A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. [MIM:601665]

From NCBI Gene: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008] From UniProt: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.

Conditions with Increased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Conditions with Decreased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.

Gene Pathways:

Metabolism

Molecular Function:

Biological Processes:

*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

UCP3 (Uncoupling protein 3)

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