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UCP1 (Uncoupling protein 1)

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Summary of UCP1

UCP encode mitochondrial transporter proteins that help release energy is in the form of heat through ATP synthesis (R). 

It is associated with higher risk for obesity (R). 

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The Function of UCP1

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

Protein names

Recommended name:

Mitochondrial brown fat uncoupling protein 1

Short name:

UCP 1

Alternative name(s):

Solute carrier family 25 member 7
Thermogenin

UCP1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1800592 (UCP1) ??
  2. RS6536991 (UCP1) ??

Top Gene-Substance Interactions

UCP1 Interacts with These Diseases

Disease Score

Fixes

FIX: Cold

Substances That Increase UCP1

Substances Interaction Organism Category

Substances That Decrease UCP1

Substances Interaction Organism Category

Advanced Summary

UCP encode mitochondrial transporter proteins that help release energy is in the form of heat through ATP synthesis (R). 

It is associated with higher risk for obesity (R). 

     From NCBI Gene: Obesity

     From NCBI Gene: Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008] From UniProt: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta
  • CREB
  • deltaCREB
  • PPAR-alpha
  • C/EBPbeta

Tissue specificity:

Brown adipose tissue.

Gene Pathways:

  • Metabolism
  • PPAR signaling pathway
  • Huntington's disease

Molecular Function:

  • Cardiolipin Binding
  • Long-Chain Fatty Acid Binding
  • Oxidative Phosphorylation Uncoupler Activity
  • Purine Ribonucleotide Binding
  • Transmembrane Transporter Activity
  • Structural Constituent Of Ribosome

Biological Processes:

  • Adaptive Thermogenesis
  • Brown Fat Cell Differentiation
  • Cellular Response To Fatty Acid
  • Cellular Response To Hormone Stimulus
  • Cellular Response To Reactive Oxygen Species
  • Mitochondrial Transmembrane Transport
  • Proton Transport
  • Regulation Of Reactive Oxygen Species Biosynthetic Process
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Response To Nutrient Levels
  • Response To Temperature Stimulus
  • Mitochondrial Transport
  • Translation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| uncoupling protein 4| CB1_002231006| D623_10033239| EGK_16117| EH28_19031| fb62c08| GW7_13076| H920_18031| I79_020576| MDA_GLEAN10017169| Mitochondrial brown fat uncoupling protein 1| mitochondrial, proton carrier| mitochondrial uncoupling protein 1| Mitochondrial uncoupling protein 2| PAL_GLEAN10016536| PANDA_016735| slc25a7| solute carrier family 25 member 7| Thermogenin| TREES_T100014574| UCP| UCP 1| UCP-1| UCP3| ucp4| Ucpa| UCPx| uncoupling protein 1, mitochondrial| uncoupling protein 1 (mitochondrial, proton carrier)| uncoupling protein 1 UCP1| uncoupling protein 2| uncoupling protein, mitochondrial| Uncp| ucp1

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