Summary of UCP1
The Function of UCP1
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Protein names
Recommended name:
Mitochondrial brown fat uncoupling protein 1Short name:
UCP 1Alternative name(s):
Solute carrier family 25 member 7Thermogenin
- RS1800592 (UCP1) ??
- RS6536991 (UCP1) ??
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Top Gene-Substance Interactions
UCP1 Interacts with These Diseases
| Disease | Score |
Fixes
FIX: Cold
Substances That Increase UCP1
| Substances | Interaction | Organism | Category |
Substances That Decrease UCP1
| Substances | Interaction | Organism | Category |
Advanced Summary
UCP encode mitochondrial transporter proteins that help release energy is in the form of heat through ATP synthesis (R).
It is associated with higher risk for obesity (R).
From NCBI Gene: Obesity
From NCBI Gene: Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008] From UniProt: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Brown adipose tissue.
Gene Pathways:
Molecular Function:
- Cardiolipin Binding
- Long-Chain Fatty Acid Binding
- Oxidative Phosphorylation Uncoupler Activity
- Purine Ribonucleotide Binding
- Transmembrane Transporter Activity
- Structural Constituent Of Ribosome
Biological Processes:
- Adaptive Thermogenesis
- Brown Fat Cell Differentiation
- Cellular Response To Fatty Acid
- Cellular Response To Hormone Stimulus
- Cellular Response To Reactive Oxygen Species
- Mitochondrial Transmembrane Transport
- Proton Transport
- Regulation Of Reactive Oxygen Species Biosynthetic Process
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Response To Nutrient Levels
- Response To Temperature Stimulus
- Mitochondrial Transport
- Translation