The Function of UCN
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma.
Top Gene-Substance Interactions
UCN Interacts with These Diseases
Disease | Score |
Substances That Increase UCN
Substances | Interaction | Organism | Category |
Substances That Decrease UCN
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481).
Molecular Function:
- Corticotropin-Releasing Hormone Activity
- Histone Deacetylase Inhibitor Activity
- Neuropeptide Hormone Activity
Biological Processes:
- Activation Of Protein Kinase A Activity
- Aerobic Respiration
- Associative Learning
- Drinking Behavior
- Female Pregnancy
- G-Protein Coupled Receptor Signaling Pathway
- Gastric Emptying
- Inflammatory Response
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Appetite
- Negative Regulation Of Blood Pressure
- Negative Regulation Of Cell Size
- Negative Regulation Of Feeding Behavior
- Negative Regulation Of Gastric Acid Secretion
- Negative Regulation Of Gene Expression
- Negative Regulation Of Hormone Secretion
- Negative Regulation Of Necrotic Cell Death
- Negative Regulation Of Neuron Death
- Neuron Projection Development
- Neuropeptide Signaling Pathway
- Pancreatic Juice Secretion
- Positive Regulation Of Behavioral Fear Response
- Positive Regulation Of Calcium Ion Import
- Positive Regulation Of Camp Biosynthetic Process
- Positive Regulation Of Cardiac Muscle Contraction
- Positive Regulation Of Cell Growth
- Positive Regulation Of Collagen Biosynthetic Process
- Positive Regulation Of Corticotropin Secretion
- Positive Regulation Of Dna Replication
- Positive Regulation Of Interleukin-6 Production
- Positive Regulation Of Peptidyl-Serine Phosphorylation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Translation
- Positive Regulation Of Vascular Permeability
- Positive Regulation Of Vasodilation
- Regulation Of Synaptic Transmission, Glutamatergic
- Response To Auditory Stimulus
- Response To Estradiol
- Response To Glucocorticoid
- Response To Oxidative Stress
- Response To Pain
- Sensory Perception Of Sound
- Social Behavior
- Startle Response