The Function of UCHL1
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Protein names
Recommended name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1Short name:
UCH-L1Alternative name(s):
Neuron cytoplasmic protein 9.5PGP 9.5
PGP9.5
Ubiquitin thioesterase L1
- RS4861096 (UCHL1) ??
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Top Gene-Substance Interactions
UCHL1 Interacts with These Diseases
| Disease | Score |
Substances That Increase UCHL1
| Substances | Interaction | Organism | Category |
Substances That Decrease UCHL1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.
Gene Pathways:
Caution:
The oxidation forms of Met-1, Met-6, Met-12, Met-124, Met-179 and Cys-220 are subject of controversy and could be the artifactual results of sample handling.
Molecular Function:
- Cysteine-Type Endopeptidase Activity
- Thiol-Dependent Ubiquitin-Specific Protease Activity
- Omega Peptidase Activity
- Ligase Activity
- Ubiquitin Protein Ligase Binding
- Alpha-2a Adrenergic Receptor Binding
- Ubiquitin Binding
Biological Processes:
- Response To Ischemia
- Axon Target Recognition
- Adult Walking Behavior
- Cell Proliferation
- Regulation Of Macroautophagy
- Protein Deubiquitination
- Sensory Perception Of Pain
- Axonal Transport Of Mitochondrion
- Eating Behavior
- Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
- Negative Regulation Of Map Kinase Activity
- Muscle Fiber Development
- Neuromuscular Process