• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. UCHL1

UCHL1 (Ubiquitin C-terminal hydrolase L1)

Loading...

The Function of UCHL1

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Ubiquitin carboxyl-terminal hydrolase isozyme L1

Short name:

UCH-L1

Alternative name(s):

Neuron cytoplasmic protein 9.5
PGP 9.5
PGP9.5
Ubiquitin thioesterase L1

UCHL1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4861096 (UCHL1) ??

Top Gene-Substance Interactions

UCHL1 Interacts with These Diseases

Disease Score

Substances That Increase UCHL1

Substances Interaction Organism Category

Substances That Decrease UCHL1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • Egr-1
  • CREB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • Pax-5
  • c-Myb

Tissue specificity:

Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.

Gene Pathways:

  • Parkinson's disease

Caution:

The oxidation forms of Met-1, Met-6, Met-12, Met-124, Met-179 and Cys-220 are subject of controversy and could be the artifactual results of sample handling.

Molecular Function:

  • Alpha-2a Adrenergic Receptor Binding
  • Cysteine-Type Endopeptidase Activity
  • Ligase Activity
  • Omega Peptidase Activity
  • Thiol-Dependent Ubiquitin-Specific Protease Activity
  • Ubiquitin Binding
  • Ubiquitin Protein Ligase Binding

Biological Processes:

  • Adult Walking Behavior
  • Axonal Transport Of Mitochondrion
  • Axon Target Recognition
  • Cell Proliferation
  • Eating Behavior
  • Muscle Fiber Development
  • Negative Regulation Of Map Kinase Activity
  • Neuromuscular Process
  • Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
  • Protein Deubiquitination
  • Regulation Of Macroautophagy
  • Response To Ischemia
  • Sensory Perception Of Pain
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_10643| AS27_09506| AS28_12350| C88048| CB1_001596001| D623_10026506| epididymis luminal protein 117| epididymis secretory protein Li 53| gad| gracile axonal dystrophy| GW7_07524| H920_05734| HEL-117| HEL-S-53| I79_024840| M959_04229| MDA_GLEAN10018680| N300_04085| N301_01868| N302_04061| N303_08378| N305_05102| N306_13405| N307_14033| N308_07748| N309_06319| N311_09462| N312_00629| N322_00941| N324_08547| N325_07414| N327_05406| N328_06181| N329_03853| N330_09409| N332_08294| N336_12327| N339_07937| N341_09928| NDGOA| Neuron cytoplasmic protein 9.5| PAL_GLEAN10016049| PARK5| pgp9.5| PGP95| PGP 9.5| protein gene product 9.5| putative ubiquitin carboxyl-terminal esterase L1 variant 1| R75593| TREES_T100003641| ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase| ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)| ubiquitin carboxylterminal esterase L1 (ubiquitin thiolesterase)| Ubiquitin carboxyl-terminal hydrolase isozyme L1| ubiquitin carboxyl-terminal hydrolase isozyme L1-like| ubiquitin carboxyl-terminal hydrolase isozyme L1-like protein| ubiquitin carboxyl-terminal hydrolase L1| ubiquitin carboxy-terminal hydrolase L1| ubiquitin C-terminal hydrolase| ubiquitin C-terminal hydrolase 1| Ubiquitin thioesterase L1| ubiquitin thiolesterase| ubiquitin thiolesterase L1| uch| uch-l1| UCHL-1| UY3_16117| Y1Q_005962| Y956_08083| Z169_05654| uchl1

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved