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  3. UBE4B

UBE4B (Ubiquitination factor E4B)

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The Function of UBE4B

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase.

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Protein names

Recommended name:

Ubiquitin conjugation factor E4 B

Alternative name(s):

Homozygously deleted in neuroblastoma 1
Ubiquitin fusion degradation protein 2

Top Gene-Substance Interactions

Substances That Increase UBE4B

Substances Interaction Organism Category

Substances That Decrease UBE4B

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Max
  • Arnt
  • c-Myc
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b
  • FOXC1
  • LCR-F1

Tissue specificity:

Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen.

Molecular Function:

  • Atp Binding
  • Enzyme Binding
  • Ligase Activity
  • Ubiquitin-Ubiquitin Ligase Activity

Biological Processes:

  • Er-Associated Ubiquitin-Dependent Protein Catabolic Process
  • Granzyme-Mediated Apoptotic Signaling Pathway
  • Neuron Projection Development
  • Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
  • Protein Autoubiquitination
  • Protein Monoubiquitination
  • Protein Polyubiquitination
  • Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
  • Response To Uv
  • Ventricular Trabecula Myocardium Morphogenesis
  • Response To Endoplasmic Reticulum Stress
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| E4| UFD2| A306_13138| AS27_13005| AS28_08712| CB1_000455013| D4Bwg0973e| D623_10021988| HDNB1| homologous to yeast UFD2| homozygously deleted in neuroblastoma-1| I79_020497| M91_12836| M959_03324| N300_05974| N301_11365| N303_02569| N307_01456| N308_08316| N309_14433| N310_08685| N311_05767| N320_03336| N321_07066| N322_01152| N324_08798| N325_07843| N326_13001| N327_04473| N328_07372| N329_12786| N330_02897| N331_05684| N332_10806| N333_05773| N334_03424| N335_11400| N336_09394| N339_06520| N340_02191| N341_03653| nicotinamide nucleotide adenylyltransferase 1| NMNAT1| PAL_GLEAN10013019| PANDA_007242| TREES_T100008710| UBE4B-III splice isoform III| UBE4B-II splice| ubiquitination factor E4B (homologous to yeast UFD2)| ubiquitination factor E4B, UFD2 homolog| ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)| ubiquitination factor E4B (UFD2 homolog, yeast)| ubiquitin conjugation factor E4 B| ubiquitin fusion degradation protein 2| ubiquitin-fusion degradation protein 2| UBOX3| ufd2a| UFD2A-III/UBE4B-III splice isoform| Ufd2p| UY3_01242| Y1Q_009600| Y956_10720| Z169_14392| ube4b

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