The Function of UBE4B
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase.
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Protein names
Recommended name:
Ubiquitin conjugation factor E4 BAlternative name(s):
Homozygously deleted in neuroblastoma 1Ubiquitin fusion degradation protein 2
Top Gene-Substance Interactions
Substances That Increase UBE4B
| Substances | Interaction | Organism | Category |
Substances That Decrease UBE4B
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen.
Molecular Function:
Biological Processes:
- Protein Polyubiquitination
- Ventricular Trabecula Myocardium Morphogenesis
- Protein Monoubiquitination
- Granzyme-Mediated Apoptotic Signaling Pathway
- Response To Uv
- Er-Associated Ubiquitin-Dependent Protein Catabolic Process
- Neuron Projection Development
- Response To Endoplasmic Reticulum Stress
- Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
- Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
- Protein Autoubiquitination