The Function of UBE4A
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
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Protein names
Recommended name:
Ubiquitin conjugation factor E4 A- RS502514 (UBE4A) ??
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Top Gene-Substance Interactions
Substances That Increase UBE4A
| Substances | Interaction | Organism | Category |
Substances That Decrease UBE4A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Er-Associated Ubiquitin-Dependent Protein Catabolic Process
- Protein Polyubiquitination
- Ubiquitin-Dependent Protein Catabolic Process