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  3. UBD

UBD (Ubiquitin D)

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The Function of UBD

Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).

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Protein names

Recommended name:

Ubiquitin D

Alternative name(s):

Diubiquitin
Ubiquitin-like protein FAT10

UBD SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11970475 (UBD) ??
  2. RS16895057 (UBD) ??

Top Gene-Substance Interactions

Substances That Increase UBD

Substances Interaction Organism Category

Substances That Decrease UBD

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • IRF-1
  • IRF-2
  • c-Rel

Tissue specificity:

Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland.

Induction:

Rapidly degraded by the proteasome. Cell-cycle regulation with highest expression during the S-phase (at protein level). Induced during dendritic cell maturation. Negatively regulated by p53/TP53. High levels in various gastrointestinal and gynecological cancer cells. Induced in RTECs in common renal diseases including diabetic nephropathy (DN), IgA nephropathy (IgAN), and hypertensive nephrosclerosis (HN), as well as in hepatocellular carcinoma (HCC) and during HIVAN. Inducible by the proinflammatory cytokines IFNG/IFN-gamma and TNF in cancers of liver and colon. Repressed by NUB1L (at protein level).

Molecular Function:

  • Proteasome Binding

Biological Processes:

  • Aggresome Assembly
  • Myeloid Dendritic Cell Differentiation
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Protein Modification By Small Protein Conjugation
  • Protein Ubiquitination
  • Proteolysis
  • Response To Interferon-Gamma
  • Response To Tumor Necrosis Factor
  • Ubiquitin-Dependent Protein Catabolic Process
  • Response To Organonitrogen Compound
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

CB1_085562013| Diubiquitin| FAT10| GABBR1| UBD-3| ubiquitin D-like protein| ubiquitin-like protein FAT10| ubd

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