The Function of U2AF1
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.
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Protein names
Recommended name:
Splicing factor U2AF 35 kDa subunitAlternative name(s):
U2 auxiliary factor 35 kDa subunitU2 small nuclear RNA auxiliary factor 1
U2 snRNP auxiliary factor small subunit
Top Gene-Substance Interactions
Substances That Increase U2AF1
| Substances | Interaction | Organism | Category |
Substances That Decrease U2AF1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Caution:
There is a duplication of the U2AF1 gene on chromosome 21. U2AF1 (AC Q01081) and U2AF1L5 (AC P0DN76) encode identical proteins.
Molecular Function:
Biological Processes:
- Mrna 3'-End Processing
- Mrna Export From Nucleus
- Mrna Processing
- Mrna Splicing, Via Spliceosome
- Positive Regulation Of Protein Targeting To Mitochondrion
- Regulation Of Mitophagy
- Rna Export From Nucleus
- Rna Splicing
- Termination Of Rna Polymerase Ii Transcription