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  3. U2AF1

U2AF1 (U2 small nuclear RNA auxiliary factor 1)

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The Function of U2AF1

Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.

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Protein names

Recommended name:

Splicing factor U2AF 35 kDa subunit

Alternative name(s):

U2 auxiliary factor 35 kDa subunit
U2 small nuclear RNA auxiliary factor 1
U2 snRNP auxiliary factor small subunit

Top Gene-Substance Interactions

Substances That Increase U2AF1

Substances Interaction Organism Category

Substances That Decrease U2AF1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Cdc5
  • AREB6
  • HSF2
  • LyF-1
  • Msx-1

Gene Pathways:

  • Gene Expression
  • Shigellosis
  • Post-Elongation Processing of the Transcript
  • Transcription

Caution:

There is a duplication of the U2AF1 gene on chromosome 21. U2AF1 (AC Q01081) and U2AF1L5 (AC P0DN76) encode identical proteins.

Molecular Function:

  • Metal Ion Binding
  • Nucleotide Binding
  • Poly(A) Rna Binding
  • Pre-Mrna 3'-Splice Site Binding

Biological Processes:

  • Mrna 3'-End Processing
  • Mrna Export From Nucleus
  • Mrna Processing
  • Mrna Splicing, Via Spliceosome
  • Positive Regulation Of Protein Targeting To Mitochondrion
  • Regulation Of Mitophagy
  • Rna Export From Nucleus
  • Rna Splicing
  • Termination Of Rna Polymerase Ii Transcription
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 35kDa| A306_12877| Anapl_15441| AS27_04909| AS28_02983| CHUNP6860| D623_10016562| FP793| M91_12136| M959_08531| MDA_GLEAN10011755| N300_12093| N301_07375| N302_08877| N303_14972| N305_07650| N306_09198| N307_05566| N308_06035| N309_14412| PAL_GLEAN10008347| putative U2 snRNP auxiliary factor small subunit variant 1| RN| RNU2AF1| splicing factor U2AF35| splicing factor U2AF 35 kDa subunit| splicing factor U2AF 35kDa subunit| splicing factor U2AF subunit-like protein| TREES_T100005960| U2AF35| U2AFBP| U2 auxiliary factor 35 kDa subunit| U2(RNU2) small nuclear RNA auxiliary factor 1| U2(RNU2) small nuclear RNA auxiliary factor binding protein| U2(RNU2) small nuclear RNA auxillary factor 1| U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1| U2 small nuclear ribonucleoprotein auxiliary factor (U2AF),35 kDa| U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit| U2 small nuclear RNA auxillary factor 1| U2 snRNP auxiliary factor small subunit| U2snRNP auxiliary factor small subunit| U2 snRNP auxiliary factor small subunit-like| Y1Q_008483| Y956_10266| Z169_11038| u2af1

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