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  2. Genes
  3. TYMS

TYMS (Thymidylate synthetase)

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The Function of TYMS

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.

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Protein names

Recommended name:

Thymidylate synthase

Short name:

TS

Alternative name(s):

TSase

TYMS SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1001761 (TYMS) ??

Top Gene-Substance Interactions

TYMS Interacts with These Diseases

Disease Score

Substances That Increase TYMS

Substances Interaction Organism Category

Substances That Decrease TYMS

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • AhR
  • Max
  • HNF-4alpha1
  • HNF-4alpha2
  • c-Myc
  • IRF-1
  • E2F-1

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Pyrimidine metabolism
  • One carbon pool by folate

Molecular Function:

  • Cofactor Binding
  • Drug Binding
  • Folic Acid Binding
  • Mrna Binding
  • Nucleotide Binding
  • Thymidylate Synthase Activity

Biological Processes:

  • Aging
  • Cartilage Development
  • Cell Growth
  • Cell Proliferation
  • Circadian Rhythm
  • Deoxyribonucleoside Monophosphate Biosynthetic Process
  • Developmental Growth
  • Dna Biosynthetic Process
  • Dtmp Biosynthetic Process
  • Dttp Biosynthetic Process
  • Dump Metabolic Process
  • G1/S Transition Of Mitotic Cell Cycle
  • Immortalization Of Host Cell By Virus
  • Intestinal Epithelial Cell Maturation
  • Liver Regeneration
  • Nucleobase-Containing Compound Metabolic Process
  • Pyrimidine Nucleoside Biosynthetic Process
  • Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
  • Regulation Of Translation
  • Response To Cytokine
  • Response To Ethanol
  • Response To Folic Acid
  • Response To Glucocorticoid
  • Response To Organophosphorus
  • Response To Progesterone
  • Response To Toxic Substance
  • Response To Vitamin A
  • Tetrahydrofolate Interconversion
  • Uracil Metabolic Process

Drug Bank:

  • Pralatrexate
  • Floxuridine
  • Fluorouracil
  • Gemcitabine
  • Leucovorin
  • Methotrexate
  • Raltitrexed
  • Trifluridine
  • Trimethoprim
  • Capecitabine
  • Pemetrexed
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_13089| AS27_05901| AS28_09405| D623_10034239| fibronectin 1| FN1| HST422| M959_00962| MDA_GLEAN10025297| N300_12947| N301_10805| N302_01012| N305_03556| N306_04836| N307_11128| N308_00733| N309_08175| N310_05059| N311_02465| N312_04332| N320_05417| N321_05563| N322_09708| N324_00179| N326_03552| N327_03340| N328_10247| N329_12151| N330_14511| N331_04456| N332_12108| N333_00284| N334_01186| N335_11826| N336_10902| N339_02643| N341_02520| PANDA_011650| thymidylate synthase| thymidylate synthase-like protein| TMS| Ts| Tsase| TYSY| UY3_11726| Y1Q_019589| Y956_04632| Z169_04920| tyms

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