The Function of TYMS
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
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Protein names
Recommended name:
Thymidylate synthaseShort name:
TSAlternative name(s):
TSase- RS1001761 (TYMS) ??
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Top Gene-Substance Interactions
TYMS Interacts with These Diseases
| Disease | Score |
Substances That Increase TYMS
| Substances | Interaction | Organism | Category |
Substances That Decrease TYMS
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Nucleotide Binding
- Mrna Binding
- Thymidylate Synthase Activity
- Folic Acid Binding
- Drug Binding
- Cofactor Binding
Biological Processes:
- G1/S Transition Of Mitotic Cell Cycle
- Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
- Nucleobase-Containing Compound Metabolic Process
- Dtmp Biosynthetic Process
- Dttp Biosynthetic Process
- Regulation Of Translation
- Aging
- Circadian Rhythm
- Cell Proliferation
- Deoxyribonucleoside Monophosphate Biosynthetic Process
- Response To Toxic Substance
- Cell Growth
- Immortalization Of Host Cell By Virus
- Uracil Metabolic Process
- Response To Progesterone
- Response To Vitamin A
- Response To Cytokine
- Tetrahydrofolate Interconversion
- Response To Ethanol
- Dump Metabolic Process
- Pyrimidine Nucleoside Biosynthetic Process
- Response To Organophosphorus
- Developmental Growth
- Cartilage Development
- Response To Glucocorticoid
- Response To Folic Acid
- Intestinal Epithelial Cell Maturation
- Dna Biosynthetic Process
- Liver Regeneration
Drug Bank:
- Pralatrexate
- Floxuridine
- Fluorouracil
- Gemcitabine
- Leucovorin
- Methotrexate
- Raltitrexed
- Trifluridine
- Trimethoprim
- Capecitabine
- Pemetrexed