The Function of TYMP
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
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Protein names
Recommended name:
Thymidine phosphorylaseShort name:
TPAlternative name(s):
GliostatinPlatelet-derived endothelial cell growth factor
PD-ECGF
TdRPase
- RS470119 (TYMP) ??
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Top Gene-Substance Interactions
TYMP Interacts with These Diseases
| Disease | Score |
Substances That Increase TYMP
| Substances | Interaction | Organism | Category |
Substances That Decrease TYMP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Phosphorylase Activity
- Pyrimidine-Nucleoside Phosphorylase Activity
- Thymidine Phosphorylase Activity
- Transferase Activity, Transferring Pentosyl Groups
- Platelet-Derived Growth Factor Receptor Binding
Biological Processes:
- Angiogenesis
- Cell Differentiation
- Chemotaxis
- Pyrimidine Nucleobase Metabolic Process
- Pyrimidine Nucleoside Catabolic Process
- Pyrimidine Nucleoside Salvage
- Dna Replication
- Mitochondrial Genome Maintenance
- Pyrimidine Nucleotide Metabolic Process