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  3. TYMP

TYMP (Thymidine phosphorylase)

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The Function of TYMP

Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

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Protein names

Recommended name:

Thymidine phosphorylase

Short name:

TP

Alternative name(s):

Gliostatin
Platelet-derived endothelial cell growth factor
PD-ECGF
TdRPase

TYMP SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS470119 (TYMP) ??

Top Gene-Substance Interactions

TYMP Interacts with These Diseases

Disease Score

Substances That Increase TYMP

Substances Interaction Organism Category

Substances That Decrease TYMP

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • Sp1
  • E2F-1

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Pyrimidine metabolism
  • Bladder cancer
  • Drug metabolism - other enzymes

Molecular Function:

  • Phosphorylase Activity
  • Pyrimidine-Nucleoside Phosphorylase Activity
  • Thymidine Phosphorylase Activity
  • Transferase Activity, Transferring Pentosyl Groups
  • Platelet-Derived Growth Factor Receptor Binding

Biological Processes:

  • Angiogenesis
  • Cell Differentiation
  • Chemotaxis
  • Pyrimidine Nucleobase Metabolic Process
  • Pyrimidine Nucleoside Catabolic Process
  • Pyrimidine Nucleoside Salvage
  • Dna Replication
  • Mitochondrial Genome Maintenance
  • Pyrimidine Nucleotide Metabolic Process

Drug Bank:

  • Capecitabine
  • Cidofovir
  • Floxuridine
  • Trifluridine
  • Fluorouracil
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| TP| ECGF| Ecgf1| endothelial cell growth factor 1 (platelet-derived)| gliostatin| GW7_00575| hPD-ECGF| MDA_GLEAN10009246| MEDPS1| MNGIE| MTDPS1| N307_06348| Odf3b| outer dense fiber of sperm tails 3B| PAL_GLEAN10004107| PDECGF| PD-ECGF| Pdgfec| platelet derived growth factor, endothelial cell| SCO2| SCO2-like protein, mitochondrial| SCO cytochrome oxidase deficient-like protein 2| tdRPase| thymidine phosphorylase isoform 1 proprotein| UY3_13692| Y1Q_023162| tymp

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