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  3. TXNRD1

TXNRD1 (Thioredoxin reductase 1)

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The Function of TXNRD1

Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.

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Protein names

Recommended name:

Thioredoxin reductase 1, cytoplasmic

Short name:

TR

Alternative name(s):

Gene associated with retinoic and interferon-induced mortality 12 protein
GRIM-12
Gene associated with retinoic and IFN-induced mortality 12 protein
KM-102-derived reductase-like factor
Thioredoxin reductase TR1

TXNRD1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS77724872 (TXNRD1) ??
  2. RS7975161 (TXNRD1) ??

Top Gene-Substance Interactions

TXNRD1 Interacts with These Diseases

Disease Score

Substances That Increase TXNRD1

Substances Interaction Organism Category

Substances That Decrease TXNRD1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • p53
  • NF-kappaB1
  • Bach1

Tissue specificity:

Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.

Gene Pathways:

  • Metabolism
  • Cellular responses to stress
  • Pyrimidine metabolism
  • Selenocompound metabolism

Induction:

Isoform 5 is induced by a combination of interferon-beta and retinoic acid (at protein level). Isoform 1 is induced by estradiol or testosterone in HeLa cells.

Cofactor:

Binds 1 FAD per subunit.

Molecular Function:

  • Electron Carrier Activity
  • Flavin Adenine Dinucleotide Binding
  • Methylseleninic Acid Reductase Activity
  • Methylselenol Reductase Activity
  • Protein Disulfide Oxidoreductase Activity
  • Thioredoxin-Disulfide Reductase Activity

Biological Processes:

  • Cell Proliferation
  • Cell Redox Homeostasis
  • Mesoderm Formation
  • Nucleobase-Containing Small Molecule Interconversion
  • Response To Reactive Oxygen Species
  • Selenium Compound Metabolic Process
  • Signal Transduction

Drug Bank:

  • Flavin Adenine Dinucleotide
  • Arsenic Trioxide
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| oxidoreductase| Tr| TR alpha| A306_07768| AS27_12518| CB1_002313014| D623_10020436| EID3| EP300 interacting inhibitor of differentiation 3| fb83a08| gene associated with retinoic and IFN-induced mortality 12 protein| gene associated with retinoic and interferon-induced mortality 12 protein| GRIM-12| H920_08304| I79_013121| KM-102-derived reductase-like factor| M959_14042| MDA_GLEAN10021920| N300_08634| N301_04608| N302_12628| N303_09352| N305_09339| N306_06415| N307_13927| N309_12763| N312_12549| N321_05882| N326_11754| N328_03289| N333_06226| N334_12200| N335_11514| N336_02961| N339_05232| N341_07394| NADPH-dependent thioredoxin reductase| PAL_GLEAN10015464| PANDA_003518| redox enzyme thioredoxin reductase| selenoprotein oxidoreductase| testis tissue sperm-binding protein Li 46a| Thioredoxin reductase 1, cytoplasmic| thioredoxin reductase 3| thioredoxin reductase GRIM-12| thioredoxin reductase TR1| TR1| TREES_T100002546| TrxR1| TXNR| UY3_12981| Y1Q_025117| Y956_15180| txnrd1

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