The Function of TWSG1
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
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Protein names
Recommended name:
Twisted gastrulation protein homolog 1Top Gene-Substance Interactions
Substances That Increase TWSG1
| Substances | Interaction | Organism | Category |
Substances That Decrease TWSG1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Developmental stage:
Expressed in brain throughout development.
Biological Processes:
- Bmp Signaling Pathway
- Camera-Type Eye Development
- Cell Differentiation
- Forebrain Development
- Hemopoiesis
- Mesoderm Formation
- Negative Regulation Of Bmp Signaling Pathway
- Negative Regulation Of Osteoblast Differentiation
- Ossification
- Positive Regulation Of Bmp Signaling Pathway
- Salivary Gland Morphogenesis