The Function of TTLL5
Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691, PubMed:22493317).
Protein names
Recommended name:
Tubulin polyglutamylase TTLL5Alternative name(s):
SRC1 and TIF2-associated modulatory proteinTubulin--tyrosine ligase-like protein 5
- RS1005224 (TTLL5) ??
- RS724743 (TTLL5) ??
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Top Gene-Substance Interactions
Substances That Increase TTLL5
| Substances | Interaction | Organism | Category |
Substances That Decrease TTLL5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the retina, found in the rod and cone photoreceptors (at protein level). Widely expressed with highest levels in heart and skeletal muscle and low levels in other tissues.
Molecular Function:
Biological Processes:
- Transcription, Dna-Templated
- Sperm Axoneme Assembly
- Fertilization
- Protein Polyglutamylation
- Flagellated Sperm Motility
- Retina Development In Camera-Type Eye
- Sperm Motility