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  3. TTLL5

TTLL5 (Tubulin tyrosine ligase like 5)

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The Function of TTLL5

Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691, PubMed:22493317).

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Protein names

Recommended name:

Tubulin polyglutamylase TTLL5

Alternative name(s):

SRC1 and TIF2-associated modulatory protein
Tubulin--tyrosine ligase-like protein 5

TTLL5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1005224 (TTLL5) ??
  2. RS724743 (TTLL5) ??

Top Gene-Substance Interactions

Substances That Increase TTLL5

Substances Interaction Organism Category

Substances That Decrease TTLL5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha

Tissue specificity:

Expressed in the retina, found in the rod and cone photoreceptors (at protein level). Widely expressed with highest levels in heart and skeletal muscle and low levels in other tissues.

Molecular Function:

  • Atp Binding
  • Ligase Activity

Biological Processes:

  • Fertilization
  • Flagellated Sperm Motility
  • Protein Polyglutamylation
  • Retina Development In Camera-Type Eye
  • Sperm Axoneme Assembly
  • Transcription, Dna-Templated
  • Sperm Motility
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| polyglutamylase| A306_08135| AS27_04482| AS28_13562| CB1_000743073| CORD19| D623_10012955| H920_14398| KIAA0998| M959_01126| N300_05642| N301_02174| N302_01805| N303_01836| N305_01056| N306_00193| N307_11562| N308_15191| N309_07571| N310_13676| N322_03286| N324_12025| N327_05875| N329_13113| N330_02890| N334_07694| N335_00563| N336_01576| N341_01918| PANDA_002690| R75373| RGD1563583| SRC1 and TIF2 associated binding protein| SRC1 and TIF2-associated modulatory protein| STAMP| TREES_T100012216| TTLL10| tubulin polyglutamylase TTLL5| tubulin polyglutamylase TTLL5-like protein| tubulin tyrosine ligase like family 5| tubulin tyrosine ligase-like family, member 10| tubulin tyrosine ligase-like family member 5| tubulin tyrosine ligase-like family, member 5| tubulin tyrosine ligase-like family, member 5 isoform 2-like protein| tubulin--tyrosine ligase-like protein 5| UY3_12113| Y1Q_004777| Z169_15329| ttll5

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