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  3. TTK

TTK (TTK protein kinase)

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The Function of TTK

Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.

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Protein names

Recommended name:

Dual specificity protein kinase TTK

Short name:

PYT

Alternative name(s):

Phosphotyrosine picked threonine-protein kinase

TTK SNPs

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  1. RS9352788 (TTK) ??

Top Gene-Substance Interactions

TTK Interacts with These Diseases

Disease Score

Substances That Increase TTK

Substances Interaction Organism Category

Substances That Decrease TTK

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Tissue specificity:

Present in rapidly proliferating cell lines.

Enzyme Regulation:

Inhibited by the ATP-competitive kinase inhibitor, SP600125.

Molecular Function:

  • Atp Binding
  • Protein Serine/Threonine/Tyrosine Kinase Activity
  • Protein Serine/Threonine Kinase Activity
  • Protein Tyrosine Kinase Activity

Biological Processes:

  • Chromosome Separation
  • Female Meiosis Chromosome Segregation
  • Meiotic Spindle Assembly Checkpoint
  • Mitotic Spindle Assembly Checkpoint
  • Mitotic Spindle Organization
  • Peptidyl-Serine Phosphorylation
  • Peptidyl-Threonine Phosphorylation
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Pathway-Restricted Smad Protein Phosphorylation
  • Protein Autophosphorylation
  • Protein Localization To Kinetochore
  • Protein Localization To Meiotic Spindle Midzone
  • Spindle Organization
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| MPS1| 0037/17| 0250/25| 0438/31| 0702/07| 1049/07| 1119/04| 1184/16| 1209/05| 1209/10| 1260/10| 1281/04| 1325/15| 1372/08| 1396/14| 1418/06| 3540| 5125| 5311| A306_00587| AL022661| anon-EST:Liang-2.9| AS27_06456| AS28_12095| AUGUSTUS-3.0.2_33029| cancer/testis antigen 96| CB1_000591030| CG1856 gene product from transcript CG1856-RE| CG1856-PA| CG1856-PB| CG1856-PC| CG1856-PD| CG1856-PE| CG1856-PF| CG1856-PG| CG1856-PH| CG8866-like| clone 2.9| CT96| Dmel_CG1856| Dual specificity protein kinase TTK| dual specificity protein kinase TTK-like protein| EGK_15107| enhancer of yan at 100D| ESK| Esk1| E(yan)100D| ftz-f2| ftzf2/ttk| GLEAN_13842| GLEAN_13843| GW7_06830| H920_02471| I79_006150| M959_03748| MDA_GLEAN10020552| mitotic checkpoint serine/threonine-protein kinase Mps1| Monopolar spindle 1| monopolar spindle 1 kinase| monopolar spindle 1-like 1| monopolar spindle protein 1| MPH1| MPS1L1| N300_01112| N301_04178| N302_15543| N305_14234| N306_02163| N307_12036| N308_11535| N309_04042| N310_10648| N311_11906| N312_13183| N320_11067| N325_12119| N326_12332| N327_09305| N328_08434| N331_00647| N332_01184| N333_01474| N334_13026| N335_14173| N336_00889| N341_02523| ncp| nightcap| osn| oss| oversensitive| ovs| PAL_GLEAN10025220| PANDA_004407| phosphotyrosine picked threonine kinase| phosphotyrosine picked threonine-protein kinase| protein nightcap| Protein tramtrack, alpha isoform-like Protein| PYT| schmal| TcasGA2_TC013842| tramtrack| tramtrack-69| Tramtrack69| Tramtrack88| tramtrak| TREES_T100001462| TTK69| TTK88| Ttk88 repressor| TTKA| ttk/FTZ-F2| ttkp69| ttk-PA| ttk-PB| ttk-PC| ttk-PD| ttk-PE| ttk-PF| ttk-PG| ttk-PH| twk| UY3_07101| Y1Q_008792| Y956_07893| Z169_16071| ttk

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