The Function of TTK
Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.
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Protein names
Recommended name:
Dual specificity protein kinase TTKShort name:
PYTAlternative name(s):
Phosphotyrosine picked threonine-protein kinase- RS9352788 (TTK) ??
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Top Gene-Substance Interactions
TTK Interacts with These Diseases
| Disease | Score |
Substances That Increase TTK
| Substances | Interaction | Organism | Category |
Substances That Decrease TTK
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Present in rapidly proliferating cell lines.
Enzyme Regulation:
Inhibited by the ATP-competitive kinase inhibitor, SP600125.
Molecular Function:
- Protein Serine/Threonine Kinase Activity
- Protein Serine/Threonine/Tyrosine Kinase Activity
- Protein Tyrosine Kinase Activity
- Atp Binding
Biological Processes:
- Spindle Organization
- Mitotic Spindle Organization
- Mitotic Spindle Assembly Checkpoint
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Pathway-Restricted Smad Protein Phosphorylation
- Female Meiosis Chromosome Segregation
- Peptidyl-Serine Phosphorylation
- Peptidyl-Threonine Phosphorylation
- Meiotic Spindle Assembly Checkpoint
- Protein Localization To Kinetochore
- Protein Autophosphorylation
- Chromosome Separation
- Protein Localization To Meiotic Spindle Midzone