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  3. TRPV6

TRPV6 (Transient receptor potential cation channel subfamily V member 6)

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The Function of TRPV6

Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.

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Protein names

Recommended name:

Transient receptor potential cation channel subfamily V member 6

Alternative name(s):

TrpV6
CaT-like
CaT-L
Calcium transport protein 1
CaT1
Epithelial calcium channel 2
ECaC2

TRPV6 SNPs

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  1. RS4987595 (TRPV6) ??

Top Gene-Substance Interactions

TRPV6 Interacts with These Diseases

Disease Score

Substances That Increase TRPV6

Substances Interaction Organism Category

Substances That Decrease TRPV6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • ARP-1
  • Roaz
  • LyF-1
  • E47
  • HNF-3beta
  • Hand1

Tissue specificity:

Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in trophoblasts of placenta villus trees (at protein level)(PubMed:23612980). Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia.

Gene Pathways:

  • Transmembrane transport of small molecules
  • Mineral absorption
  • Salivary secretion

Molecular Function:

  • Calcium Channel Activity
  • Calmodulin Binding
  • Metal Ion Binding

Biological Processes:

  • Calcium Ion Homeostasis
  • Calcium Ion Import Into Cell
  • Calcium Ion Transmembrane Transport
  • Calcium Ion Transport
  • Regulation Of Calcium Ion-Dependent Exocytosis
  • Response To Calcium Ion
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| transient receptor potential cation channel, subfamily V, member 5| ABP/ZF| Alu-binding protein with zinc finger domain| Cac| calcium transporter-like protein| calcium transport protein 1| CaT| CaT1| CATL| CB1_000804061| D623_10026162| ECaC| ECAC2| epithelial apical membrane calcium transporter/channel CaT1| epithelial calcium channel| epithelial calcium channel 2| H920_16490| HSA277909| I79_011407| LP6728| M959_01738| matt-und-schlapp| MDA_GLEAN10005344| mus| N307_10705| N331_06716| osmosensitive transient receptor potential channel 3| Otrpc3| PANDA_013512| putative TRPV6| transient receptor potential cation channel, subfamily 5, member 6| Transient receptor potential cation channel subfamily V member 5| transient receptor potential cation channel, subfamily V, member 6| transient receptor potential vanilloid 5-6| Transient receptor putative cation channel subfamily V member 6| trpv5-6| UY3_15391| Y956_10146| ZFAB| trpv6

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