The Function of TRPV6
Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
Protein names
Recommended name:
Transient receptor potential cation channel subfamily V member 6Alternative name(s):
TrpV6CaT-like
CaT-L
Calcium transport protein 1
CaT1
Epithelial calcium channel 2
ECaC2
- RS4987595 (TRPV6) ??
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Top Gene-Substance Interactions
TRPV6 Interacts with These Diseases
| Disease | Score |
Substances That Increase TRPV6
| Substances | Interaction | Organism | Category |
Substances That Decrease TRPV6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in trophoblasts of placenta villus trees (at protein level)(PubMed:23612980). Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia.
Molecular Function:
Biological Processes:
- Calcium Ion Homeostasis
- Calcium Ion Import Into Cell
- Calcium Ion Transmembrane Transport
- Calcium Ion Transport
- Regulation Of Calcium Ion-Dependent Exocytosis
- Response To Calcium Ion