The Function of TRPS1
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.
Protein names
Recommended name:
Zinc finger transcription factor Trps1Alternative name(s):
Tricho-rhino-phalangeal syndrome type I proteinZinc finger protein GC79
- RS13281609 (TRPS1) ??
- RS16886173 (TRPS1) ??
- RS17658378 (TRPS1) ??
- RS1845529 (TRPS1) ??
- RS218361 (TRPS1) ??
- RS2293889 (TRPS1) ??
- RS2721937 (TRPS1) ??
- RS2737229 (TRPS1) ??
- RS6983039 (TRPS1) ??
- RS7014900 (TRPS1) ??
- RS800586 (TRPS1) ??
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Top Gene-Substance Interactions
TRPS1 Interacts with These Diseases
| Disease | Score |
Substances That Increase TRPS1
| Substances | Interaction | Organism | Category |
Substances That Decrease TRPS1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells.
Molecular Function:
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Transcription Factor Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Chromatin Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Zinc Ion Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Skeletal System Development
- Transcription From Rna Polymerase Ii Promoter
- Nls-Bearing Protein Import Into Nucleus
- Heart Development
- Animal Organ Morphogenesis
- Tissue Development
- Regulation Of Chondrocyte Differentiation
- Cell Fate Commitment
- Cell Development
- Digestive Tract Development
- Anatomical Structure Formation Involved In Morphogenesis