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  3. TRPS1

TRPS1 (Transcriptional repressor GATA binding 1)

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The Function of TRPS1

Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.

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Protein names

Recommended name:

Zinc finger transcription factor Trps1

Alternative name(s):

Tricho-rhino-phalangeal syndrome type I protein
Zinc finger protein GC79

TRPS1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS13281609 (TRPS1) ??
  2. RS16886173 (TRPS1) ??
  3. RS17658378 (TRPS1) ??
  4. RS1845529 (TRPS1) ??
  5. RS218361 (TRPS1) ??
  6. RS2293889 (TRPS1) ??
  7. RS2721937 (TRPS1) ??
  8. RS2737229 (TRPS1) ??
  9. RS6983039 (TRPS1) ??
  10. RS7014900 (TRPS1) ??
  11. RS800586 (TRPS1) ??

Top Gene-Substance Interactions

TRPS1 Interacts with These Diseases

Disease Score

Substances That Increase TRPS1

Substances Interaction Organism Category

Substances That Decrease TRPS1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • STAT3
  • c-Myc

Tissue specificity:

Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells.

Molecular Function:

  • Chromatin Binding
  • Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Transcription Factor Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Zinc Ion Binding

Biological Processes:

  • Anatomical Structure Formation Involved In Morphogenesis
  • Animal Organ Morphogenesis
  • Cell Development
  • Cell Fate Commitment
  • Digestive Tract Development
  • Heart Development
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Nls-Bearing Protein Import Into Nucleus
  • Regulation Of Chondrocyte Differentiation
  • Skeletal System Development
  • Tissue Development
  • Transcription From Rna Polymerase Ii Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| LGCR| A306_05000| AS27_11142| AS28_00869| CB1_002448002| D15Ertd586e| D623_10016589| GC79| I79_003563| M91_19964| M959_11416| MDA_GLEAN10007670| N300_08505| N301_04676| N302_07502| N303_00242| N305_10977| N306_02546| N307_03327| N309_07925| N310_11690| N312_08962| N321_11822| N324_06333| N325_08581| N326_07358| N327_07349| N328_05917| N329_08702| N330_00806| N331_00650| N332_02888| N333_01072| N335_08824| N336_01554| N340_09489| N341_02629| PAL_GLEAN10021422| PANDA_007849| transcription factor Trps1| TREES_T100014560| trichorhinophalangeal syndrome I| trichorhinophalangeal syndrome I homolog| trichorhinophalangeal syndrome I (human)| tricho-rhino-phalangeal syndrome type I protein| UY3_13172| Y1Q_014027| Y956_13172| Z169_01505| zinc finger protein GC79| zinc finger transcription factor Trps1| trps1

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