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  3. TRPM7

TRPM7 (Transient receptor potential cation channel subfamily M member 7)

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Summary of TRPM7

This gene encodes a protein that is essential for the ion channel function. It increases intracellular calcium levels and help regulate magnesium ion homeostasis (R).

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The Function of TRPM7

Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).

Protein names

Recommended name:

Transient receptor potential cation channel subfamily M member 7

Alternative name(s):

Channel-kinase 1
Long transient receptor potential channel 7
LTrpC-7
LTrpC7

TRPM7 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11070795 (TRPM7) ??
  2. RS11635825 (TRPM7) ??
  3. RS2414059 (TRPM7) ??
  4. RS3105593 (TRPM7) ??
  5. RS4775899 (TRPM7) ??
  6. RS616256 (TRPM7) ??
  7. RS7173321 (TRPM7) ??
  8. RS8042919 (TRPM7) ??

Top Gene-Substance Interactions

TRPM7 Interacts with These Diseases

Disease Score

Substances That Increase TRPM7

Substances Interaction Organism Category

Substances That Decrease TRPM7

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: amyotrophic lateral sclerosisFrom NCBI Gene: Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1From UniProt: Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1): A neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual. [MIM:105500]

     From NCBI Gene: The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014] From UniProt: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • Arnt
  • Nkx2-5
  • Meis-1
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b
  • Meis-1b

Gene Pathways:

  • Transmembrane transport of small molecules
  • Mineral absorption

Cofactor:

Binds 1 zinc ion per subunit.

Molecular Function:

  • Atp Binding
  • Calcium Channel Activity
  • Metal Ion Binding
  • Protein Serine/Threonine Kinase Activity

Biological Processes:

  • Actomyosin Structure Organization
  • Calcium-Dependent Cell-Matrix Adhesion
  • Calcium Ion Transmembrane Transport
  • Cellular Magnesium Ion Homeostasis
  • Necroptotic Process
  • Protein Autophosphorylation
  • Protein Tetramerization
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| transient receptor potential cation channel, subfamily M, member| transient receptor potential cation channel, subfamily M, member 7| A306_13656| ALSPDC| Chak| CHAK1| channel-kinase 1| D623_10026021| GW7_20257| long transient receptor potential channel 7| Ltpr7| Ltrpc7| LTrpC-7| LTRPC ion channel family member 7| MDA_GLEAN10016349| N311_03020| N322_03381| N339_07703| nutria| PANDA_009197| Putative ubiquitin carboxyl-terminal hydrolase 50| tct| touchtone| transient receptor potential M7| transient receptor potential melastatin 7| transient receptor potential-phospholipase C-interacting kinase| transient receptor potential-related protein, ChaK| trp-plik| TRPPLIK| UY3_13727| xtrpm7| trpm7

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