Summary of TRPM7
The Function of TRPM7
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Protein names
Recommended name:
Transient receptor potential cation channel subfamily M member 7Alternative name(s):
Channel-kinase 1Long transient receptor potential channel 7
LTrpC-7
LTrpC7
- RS11070795 (TRPM7) ??
- RS11635825 (TRPM7) ??
- RS2414059 (TRPM7) ??
- RS3105593 (TRPM7) ??
- RS4775899 (TRPM7) ??
- RS616256 (TRPM7) ??
- RS7173321 (TRPM7) ??
- RS8042919 (TRPM7) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
TRPM7 Interacts with These Diseases
| Disease | Score |
Substances That Increase TRPM7
| Substances | Interaction | Organism | Category |
Substances That Decrease TRPM7
| Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: amyotrophic lateral sclerosisFrom NCBI Gene: Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1From UniProt: Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1): A neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual. [MIM:105500]
From NCBI Gene: The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014] From UniProt: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Cofactor:
Binds 1 zinc ion per subunit.
Molecular Function:
Biological Processes:
- Actomyosin Structure Organization
- Calcium-Dependent Cell-Matrix Adhesion
- Calcium Ion Transmembrane Transport
- Cellular Magnesium Ion Homeostasis
- Necroptotic Process
- Protein Autophosphorylation
- Protein Tetramerization