Summary of TRPM3
This Gene influences Chronic Fatigue Syndrome.
"...the involvement of TRPM3 receptors could explain why so many patients appear to experience CFS/ME following a traumatic event or serious infection.
The class of receptors TRPM3 belongs to are also known as 'threat receptors', because they're upregulated when the body is under any kind of threat, such as infection, trauma, or even childbirth.
Staines and his colleagues predict that it's this upregulation that causes the faulty genetic receptors to get over-expressed and then take over, messing up the calcium transfer in a range of cells." (R)
The Function of TRPM3
Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.
Protein names
Recommended name:
Transient receptor potential cation channel subfamily M member 3Short name:
MLSN2Alternative name(s):
Long transient receptor potential channel 3LTrpC-3
LTrpC3
Melastatin-2
- RS10780944 (TRPM3) ??
- RS2043144 (TRPM3) ??
- RS2309891 (TRPM3) ??
- RS4745062 (TRPM3) ??
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Top Gene-Substance Interactions
Substances That Increase TRPM3
| Substances | Interaction | Organism | Category |
Substances That Decrease TRPM3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney.
Gene Pathways:
Molecular Function:
Biological Processes:
- Calcium Ion Transmembrane Transport
- Cation Transport
- Detection Of Temperature Stimulus
- Protein Tetramerization
- Sensory Perception Of Temperature Stimulus