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  3. TRPM3

TRPM3 (Transient receptor potential cation channel subfamily M member 3)

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Summary of TRPM3

This Gene influences Chronic Fatigue Syndrome.

"...the involvement of TRPM3 receptors could explain why so many patients appear to experience CFS/ME following a traumatic event or serious infection.

The class of receptors TRPM3 belongs to are also known as 'threat receptors', because they're upregulated when the body is under any kind of threat, such as infection, trauma, or even childbirth. 

Staines and his colleagues predict that it's this upregulation that causes the faulty genetic receptors to get over-expressed and then take over, messing up the calcium transfer in a range of cells." (R)

It's better to have this gene decreased most of the time.
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The Function of TRPM3

Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.

Protein names

Recommended name:

Transient receptor potential cation channel subfamily M member 3

Short name:

MLSN2

Alternative name(s):

Long transient receptor potential channel 3
LTrpC-3
LTrpC3
Melastatin-2

TRPM3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10780944 (TRPM3) ??
  2. RS2043144 (TRPM3) ??
  3. RS2309891 (TRPM3) ??
  4. RS4745062 (TRPM3) ??

Top Gene-Substance Interactions

Substances That Increase TRPM3

Substances Interaction Organism Category

Substances That Decrease TRPM3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • GR
  • GR-alpha
  • MEF-2A
  • ARP-1

Tissue specificity:

Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney.

Gene Pathways:

  • Transmembrane transport of small molecules

Molecular Function:

  • Calcium Activated Cation Channel Activity
  • Calcium Channel Activity
  • Cation Channel Activity

Biological Processes:

  • Calcium Ion Transmembrane Transport
  • Cation Transport
  • Detection Of Temperature Stimulus
  • Protein Tetramerization
  • Sensory Perception Of Temperature Stimulus
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 9330180E14| A306_02767| AS27_02939| CB1_026915009| D623_10034436| GON-2| GW7_17402| H920_11407| long transient receptor potential channel 3| LTrpC-3| LTRPC3| M91_01890| M959_07794| MDA_GLEAN10017992| melastatin 2| melastatin-2| MLSN2| N300_09213| N301_11838| N302_14681| N303_10538| N305_12175| N308_01264| N322_00843| N324_02172| N329_11798| N330_08810| N333_05420| N339_02546| PAL_GLEAN10021086| PANDA_002713| transient receptor potential cation channel, subfamily M, member 1a| transient receptor potential cation channel, subfamily M, member 3| transient receptor potential cation channel, subfamily M, member 6| transient receptor potential melastatin 3| transient receptor potential melastatin 3 beta 1| transient receptor potential melastatin 3 beta 10| transient receptor potential melastatin 3 beta 11| transient receptor potential melastatin 3 beta 12| transient receptor potential melastatin 3 beta 13| transient receptor potential melastatin 3 beta 14| transient receptor potential melastatin 3 beta 15| transient receptor potential melastatin 3 beta 16| transient receptor potential melastatin 3 beta 17| transient receptor potential melastatin 3 beta 2| transient receptor potential melastatin 3 beta 3| transient receptor potential melastatin 3 beta 4| transient receptor potential melastatin 3 beta 5| transient receptor potential melastatin 3 beta 6| transient receptor potential melastatin 3 beta 7| transient receptor potential melastatin 3 beta 8| transient receptor potential melastatin 3 beta 9| Transient receptor putative cation channel subfamily M member 3| TREES_T100009981| TRPM1A| trpm6| UY3_12443| Y1Q_012759| trpm3

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