The Function of TREM1
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
Protein names
Recommended name:
Triggering receptor expressed on myeloid cells 1Short name:
TREM-1Alternative name(s):
Triggering receptor expressed on monocytes 1CD antigen CD354
- RS74851542 (TREM1) ??
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Top Gene-Substance Interactions
TREM1 Interacts with These Diseases
| Disease | Score |
Substances That Increase TREM1
| Substances | Interaction | Organism | Category |
Substances That Decrease TREM1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.
Gene Pathways:
Induction:
Up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS).
Molecular Function:
Biological Processes:
- Chemokine Metabolic Process
- Cytokine Secretion Involved In Immune Response
- Humoral Immune Response
- Innate Immune Response
- Intracellular Signal Transduction
- Leukocyte Migration
- Neutrophil Chemotaxis
- Neutrophil Extravasation
- Neutrophil Mediated Killing Of Gram-Negative Bacterium
- Regulation Of Immune Response
- Mitophagy In Response To Mitochondrial Depolarization
- Positive Regulation Of Defense Response To Virus By Host
- Xenophagy