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  3. TPH2

TPH2 (Tryptophan hydroxylase 2)

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Summary of TPH2

TPH2 is the most important enzyme that makes serotonin (rate limiting) [R].  TPH2 is produced most significantly in the brain stem [R].

Variants of TPH2 with impaired enzyme activity could cause a deficiency of serotonin production and result in an increased risk of developing behavioral disorders [R].

Mutations in this gene may be associated with psychiatric diseases such as bipolar, major depression [R] and ADHD [R].

It's better to have this gene increased most of the time.
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Protein names

Recommended name:

Tryptophan 5-hydroxylase 2

Alternative name(s):

Neuronal tryptophan hydroxylase
Tryptophan 5-monooxygenase 2

TPH2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10506645 (TPH2) ??
  2. RS10879357 (TPH2) ??
  3. RS11178997 (TPH2) ??
  4. RS1386491 (TPH2) ??
  5. RS1386494 (TPH2) ??
  6. RS1487275 (TPH2) ??
  7. RS1487278 (TPH2) ??
  8. RS1571218 (TPH2) ??
  9. RS17110563 (TPH2) ??
  10. RS17110690 (TPH2) ??
  11. RS1843809 (TPH2) ??
  12. RS2171363 (TPH2) ??
  13. RS4290270 (TPH2) ??
  14. RS4565946 (TPH2) ??
  15. RS4570625 (TPH2) ??

Top Gene-Substance Interactions

TPH2 Interacts with These Diseases

Disease Score

Fixes

How to increase serotonin:

  • Bright light,
  • 5-HTP,
  • L-tryptophan,

Fixes Advanced

Drugs that increase serotonin:

  • Tricyclic antidepressants (TCAs) [R].
  • MAOIs [R].
  • SSRIs [R].

Substances That Increase TPH2

Substances Interaction Organism Category

Substances That Decrease TPH2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta

Tissue specificity:

Brain specific.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Tryptophan metabolism

Molecular Function:

  • Amino Acid Binding
  • Iron Ion Binding
  • Tryptophan 5-Monooxygenase Activity

Biological Processes:

  • Aromatic Amino Acid Family Metabolic Process
  • Cellular Response To Lithium Ion
  • Circadian Rhythm
  • Indolalkylamine Biosynthetic Process
  • Response To Calcium Ion
  • Response To Estrogen
  • Response To Glucocorticoid
  • Response To Nutrient Levels
  • Serotonin Biosynthetic Process

Drug Bank:

  • L-Tryptophan
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_09762| ADHD7| AS27_09666| AS28_00949| CB1_001443020| D623_10034072| EH28_13069| H920_02332| I79_005262| M959_06810| MDA_GLEAN10018431| N300_08330| N301_01464| N302_08847| N303_04479| N305_08856| N306_04350| N307_04231| N308_02105| N309_06445| N310_00984| N311_07035| N312_00704| N321_00509| N322_02430| N327_08242| N328_12101| N329_11504| N330_11797| N331_12509| N332_09503| N336_03597| N339_06405| N340_13470| N341_03802| neuronal tryptophan hydroxylase| neuronal tryptophan hydroxylase 2| NTPH| PAL_GLEAN10022399| PANDA_003666| tph2a| tphR| TREES_T100013109| tryptophan 5-hydroxylase 2| tryptophan 5-monooxygenase 2| tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)| tryptophan hydroxylase R| UY3_02293| Y1Q_031462| Y956_11116| Z169_14266| tph2

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