Summary of TPH2
TPH2 is the most important enzyme that makes serotonin (rate limiting) [R]. TPH2 is produced most significantly in the brain stem [R].
Variants of TPH2 with impaired enzyme activity could cause a deficiency of serotonin production and result in an increased risk of developing behavioral disorders [R].
Mutations in this gene may be associated with psychiatric diseases such as bipolar, major depression [R] and ADHD [R].
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Protein names
Recommended name:
Tryptophan 5-hydroxylase 2Alternative name(s):
Neuronal tryptophan hydroxylaseTryptophan 5-monooxygenase 2
- RS10506645 (TPH2) ??
- RS10879357 (TPH2) ??
- RS11178997 (TPH2) ??
- RS1386491 (TPH2) ??
- RS1386494 (TPH2) ??
- RS1487275 (TPH2) ??
- RS1487278 (TPH2) ??
- RS1571218 (TPH2) ??
- RS17110563 (TPH2) ??
- RS17110690 (TPH2) ??
- RS1843809 (TPH2) ??
- RS2171363 (TPH2) ??
- RS4290270 (TPH2) ??
- RS4565946 (TPH2) ??
- RS4570625 (TPH2) ??
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Top Gene-Substance Interactions
TPH2 Interacts with These Diseases
| Disease | Score |
Fixes
Substances That Increase TPH2
| Substances | Interaction | Organism | Category |
Substances That Decrease TPH2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Brain specific.
Gene Pathways:
Molecular Function:
Biological Processes:
- Aromatic Amino Acid Family Metabolic Process
- Cellular Response To Lithium Ion
- Circadian Rhythm
- Indolalkylamine Biosynthetic Process
- Response To Calcium Ion
- Response To Estrogen
- Response To Glucocorticoid
- Response To Nutrient Levels
- Serotonin Biosynthetic Process