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  3. TOX3

TOX3 (TOX high mobility group box family member 3)

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The Function of TOX3

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.

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Protein names

Recommended name:

TOX high mobility group box family member 3

Alternative name(s):

CAG trinucleotide repeat-containing gene F9 protein
Trinucleotide repeat-containing gene 9 protein

TOX3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12443621 (TOX3) ??
  2. RS2193094 (TOX3) ??
  3. RS4784223 (TOX3) ??
  4. RS8051542 (TOX3) ??

Top Gene-Substance Interactions

Substances That Increase TOX3

Substances Interaction Organism Category

Substances That Decrease TOX3

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: restless legs syndromebreast cancer

     From NCBI Gene: The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer . Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009] From UniProt: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Nkx3-1 v1

Tissue specificity:

Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe.

Induction:

Up-regulated by GPR39 in neuronal cells.

Molecular Function:

  • Chromatin Binding
  • Estrogen Response Element Binding
  • Phosphoprotein Binding
  • Protein Homodimerization Activity

Biological Processes:

  • Apoptotic Process
  • Negative Regulation Of Neuron Apoptotic Process
  • Positive Regulation Of Transcription, Dna-Templated
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 500-9| A306_01627| AS27_09132| AS28_12894| C230068E13| cagf9| CAG trinucleotide repeat-containing gene F9 protein| CB1_000681026| D623_10024544| GW7_19788| H920_00710| I79_003718| M91_17862| M959_09704| N300_03853| N301_11313| N302_07068| N303_01415| N305_11145| N306_09466| N307_12473| N308_03939| N309_02366| N310_07858| N311_06748| N312_06242| N320_01536| N321_02497| N322_12797| N324_09882| N325_12781| N326_12006| N327_04470| N328_02084| N330_02943| N331_07525| N332_14625| N333_04370| N334_06951| N335_06069| N336_06895| N339_12624| N340_00526| N341_12858| PAL_GLEAN10011025| Tnrc9| TOX high mobility group box family member 3-like protein| TREES_T100017251| trinucleotide repeat containing 9| trinucleotide repeat-containing gene 9 protein| UY3_01520| Y1Q_011160| Y956_15455| Z169_07476| tox3

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