The Function of TOX3
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.
Protein names
Recommended name:
TOX high mobility group box family member 3Alternative name(s):
CAG trinucleotide repeat-containing gene F9 proteinTrinucleotide repeat-containing gene 9 protein
- RS12443621 (TOX3) ??
- RS2193094 (TOX3) ??
- RS4784223 (TOX3) ??
- RS8051542 (TOX3) ??
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Top Gene-Substance Interactions
Substances That Increase TOX3
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Substances That Decrease TOX3
Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: restless legs syndromebreast cancer
From NCBI Gene: The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer . Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009] From UniProt: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe.
Induction:
Up-regulated by GPR39 in neuronal cells.
Molecular Function:
- Chromatin Binding
- Estrogen Response Element Binding
- Phosphoprotein Binding
- Protein Homodimerization Activity
Biological Processes:
- Apoptotic Process
- Negative Regulation Of Neuron Apoptotic Process
- Positive Regulation Of Transcription, Dna-Templated
- Transcription, Dna-Templated