Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

     Covered on Genetics Home Reference: restless legs syndromebreast cancer

     From NCBI Gene: The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer . Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009] From UniProt: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• Nkx3-1 v1

Tissue specificity:

Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe.

Induction:

Up-regulated by GPR39 in neuronal cells.

Molecular Function:

• Chromatin Binding
• Estrogen Response Element Binding
• Phosphoprotein Binding
• Protein Homodimerization Activity

Biological Processes:

• Apoptotic Process
• Negative Regulation Of Neuron Apoptotic Process
• Positive Regulation Of Transcription, Dna-Templated
• Transcription, Dna-Templated

*synonyms