The Function of TOP2A
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation.
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Protein names
Recommended name:
DNA topoisomerase 2-alphaAlternative name(s):
DNA topoisomerase II, alpha isozyme- RS584438 (TOP2A) ??
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Top Gene-Substance Interactions
TOP2A Interacts with These Diseases
| Disease | Score |
Substances That Increase TOP2A
| Substances | Interaction | Organism | Category |
Substances That Decrease TOP2A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Enzyme Regulation:
Specifically inhibited by the intercalating agent amsacrine.
Cofactor:
Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
Molecular Function:
- Magnesium Ion Binding
- Dna Binding
- Chromatin Binding
- Dna Topoisomerase Type Ii (Atp-Hydrolyzing) Activity
- Protein Kinase C Binding
- Atp Binding
- Protein C-Terminus Binding
- Dna-Dependent Atpase Activity
- Drug Binding
- Dna Binding, Bending
- Enzyme Binding
- Protein Homodimerization Activity
- Histone Deacetylase Binding
- Ubiquitin Binding
- Poly(A) Rna Binding
- Protein Heterodimerization Activity
Biological Processes:
- Resolution Of Meiotic Recombination Intermediates
- Sister Chromatid Segregation
- Hematopoietic Progenitor Cell Differentiation
- Dna Topological Change
- Dna Ligation
- Dna Unwinding Involved In Dna Replication
- Mitotic Recombination
- Cellular Response To Dna Damage Stimulus
- Chromosome Segregation
- Protein Sumoylation
- Apoptotic Chromosome Condensation
- Embryonic Cleavage
- Regulation Of Circadian Rhythm
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Viral Genome Replication
- Positive Regulation Of Single Stranded Viral Rna Replication Via Double Stranded Dna Intermediate
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Rhythmic Process
- Mitotic Dna Integrity Checkpoint
Drug Bank:
- Podofilox
- Ciprofloxacin
- Dactinomycin
- Daunorubicin
- Dexrazoxane
- Doxorubicin
- Enoxacin
- Etoposide
- Finafloxacin
- Fleroxacin
- Idarubicin
- Levofloxacin
- Lucanthone
- Mitoxantrone
- Moxifloxacin
- Norfloxacin
- Ofloxacin
- Pefloxacin
- Teniposide
- Trovafloxacin
- Valrubicin
- Amsacrine
- Epirubicin
- Lomefloxacin
- Sparfloxacin