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  3. TOP2A

TOP2A (Topoisomerase (DNA) II alpha)

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The Function of TOP2A

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation.

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Protein names

Recommended name:

DNA topoisomerase 2-alpha

Alternative name(s):

DNA topoisomerase II, alpha isozyme

TOP2A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS584438 (TOP2A) ??

Top Gene-Substance Interactions

TOP2A Interacts with These Diseases

Disease Score

Substances That Increase TOP2A

Substances Interaction Organism Category

Substances That Decrease TOP2A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • E2F-1

Enzyme Regulation:

Specifically inhibited by the intercalating agent amsacrine.

Cofactor:

Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).

Molecular Function:

  • Atp Binding
  • Chromatin Binding
  • Dna Binding
  • Dna Binding, Bending
  • Dna-Dependent Atpase Activity
  • Dna Topoisomerase Type Ii (Atp-Hydrolyzing) Activity
  • Drug Binding
  • Enzyme Binding
  • Histone Deacetylase Binding
  • Magnesium Ion Binding
  • Poly(A) Rna Binding
  • Protein C-Terminus Binding
  • Protein Heterodimerization Activity
  • Protein Homodimerization Activity
  • Protein Kinase C Binding
  • Ubiquitin Binding

Biological Processes:

  • Apoptotic Chromosome Condensation
  • Cellular Response To Dna Damage Stimulus
  • Chromosome Segregation
  • Dna Ligation
  • Dna Topological Change
  • Dna Unwinding Involved In Dna Replication
  • Embryonic Cleavage
  • Hematopoietic Progenitor Cell Differentiation
  • Mitotic Dna Integrity Checkpoint
  • Mitotic Recombination
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Single Stranded Viral Rna Replication Via Double Stranded Dna Intermediate
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Viral Genome Replication
  • Protein Sumoylation
  • Regulation Of Circadian Rhythm
  • Resolution Of Meiotic Recombination Intermediates
  • Rhythmic Process
  • Sister Chromatid Segregation

Drug Bank:

  • Podofilox
  • Ciprofloxacin
  • Dactinomycin
  • Daunorubicin
  • Dexrazoxane
  • Doxorubicin
  • Enoxacin
  • Etoposide
  • Finafloxacin
  • Fleroxacin
  • Idarubicin
  • Levofloxacin
  • Lucanthone
  • Mitoxantrone
  • Moxifloxacin
  • Norfloxacin
  • Ofloxacin
  • Pefloxacin
  • Teniposide
  • Trovafloxacin
  • Valrubicin
  • Amsacrine
  • Epirubicin
  • Lomefloxacin
  • Sparfloxacin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_12185| AS27_11193| AS28_09342| CB1_001119003| D623_10030360| DNA gyrase| DNA topoisomerase 2-alpha| DNA topoisomerase 2-alpha-like| DNA topoisomerase 2-alpha-like protein| DNA topoisomerase (ATP-hydrolyzing)| DNA topoisomerase II, 170 kD| DNA topoisomerase II alpha| DNA topoisomeraseII_alpha| DNA topoisomerase II, alpha isozyme| fc08c07| H920_03580| M91_05302| M959_15226| N300_06128| N302_08163| N303_00628| N306_07273| N308_02367| N309_02228| N312_06845| N320_01101| N321_08950| N322_09338| N326_07977| N327_11941| N328_10959| N335_05893| N340_13750| N341_08617| PAL_GLEAN10019593| Top-2| TOP2| TOPOII| topoisomerase 2| topoisomerase (DNA) 2 alpha| topoisomerase (DNA) II alpha 170kDa| topoisomerase II alpha 170kDa| topoisomersae II| TP2A| TREES_T100004440| Y1Q_015107| Z169_13721| top2a

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