The Function of TNR
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance.
Protein names
Recommended name:
Tenascin-RShort name:
TN-RAlternative name(s):
JanusinRestrictin
- RS17312292 (TNR) ??
- RS3766680 (TNR) ??
- RS859427 (TNR) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
TNR Interacts with These Diseases
| Disease | Score |
Substances That Increase TNR
| Substances | Interaction | Organism | Category |
Substances That Decrease TNR
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Brain specific.
Gene Pathways:
Biological Processes:
- Associative Learning
- Axon Guidance
- Cell Adhesion
- Extracellular Matrix Organization
- Locomotory Exploration Behavior
- Long-Term Synaptic Potentiation
- Negative Regulation Of Axon Extension Involved In Regeneration
- Negative Regulation Of Cell-Cell Adhesion
- Negative Regulation Of Synaptic Transmission
- Neuromuscular Process Controlling Balance
- Neuron Cell-Cell Adhesion
- Positive Regulation Of Synaptic Transmission, Glutamatergic
- Positive Regulation Of Transmission Of Nerve Impulse
- Synapse Organization
- Telencephalon Cell Migration