The Function of TNFSF13
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
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Protein names
Recommended name:
Tumor necrosis factor ligand superfamily member 13Short name:
APRILAlternative name(s):
A proliferation-inducing ligandTNF- and APOL-related leukocyte expressed ligand 2
TALL-2
TNF-related death ligand 1
TRDL-1
CD antigen CD256
- RS11552708 (TNFSF13) ??
- RS3803800 (TNFSF13) ??
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Top Gene-Substance Interactions
Substances That Increase TNFSF13
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Substances That Decrease TNFSF13
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Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.
Gene Pathways:
Induction:
Down-regulated by phorbol myristate acetate/ionomycin treatment.
Molecular Function:
Biological Processes:
- Immune Response
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Isotype Switching To Iga Isotypes
- Regulation Of Mrna Stability
- Signal Transduction
- Tumor Necrosis Factor-Mediated Signaling Pathway