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  3. TNFSF13

TNFSF13 (Tumor necrosis factor superfamily member 13)

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The Function of TNFSF13

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.

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Protein names

Recommended name:

Tumor necrosis factor ligand superfamily member 13

Short name:

APRIL

Alternative name(s):

A proliferation-inducing ligand
TNF- and APOL-related leukocyte expressed ligand 2
TALL-2
TNF-related death ligand 1
TRDL-1
CD antigen CD256

TNFSF13 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11552708 (TNFSF13) ??
  2. RS3803800 (TNFSF13) ??

Top Gene-Substance Interactions

Substances That Increase TNFSF13

Substances Interaction Organism Category

Substances That Decrease TNFSF13

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • CREB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • C/EBPbeta
  • c-Fos
  • STAT1
  • STAT1beta
  • STAT1alpha

Tissue specificity:

Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.

Gene Pathways:

  • Gene Expression
  • Cytokine-cytokine receptor interaction
  • Intestinal immune network for IgA production
  • Metabolism of RNA
  • Rheumatoid arthritis

Induction:

Down-regulated by phorbol myristate acetate/ionomycin treatment.

Molecular Function:

  • Receptor Binding

Biological Processes:

  • Immune Response
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Isotype Switching To Iga Isotypes
  • Regulation Of Mrna Stability
  • Signal Transduction
  • Tumor Necrosis Factor-Mediated Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| april| april protein| A proliferation-inducing ligand| CD256| H920_19740| I79_002750| MDA_GLEAN10018304| PAL_GLEAN10010192| proliferation-inducing ligand| Tall2| TALL-2| tnf13| TNF- and APOL-related leukocyte expressed ligand 2| TNF superfamily member 13| TNLG7B| Trdl1| TRDL-1| tumor necrosis factor ligand 7b| tumor necrosis factor (ligand) superfamily, member 13| Tumor necrosis factor ligand superfamily member 13| tumor necrosis factor ligand superfamily member 13 isoform alpha proprotein| tumor necrosis factor-like protein ZTNF2| tumor necrosis factor-related death ligand-1| UNQ383/PRO715| ZTNF2| tnfsf13

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