The Function of TNFSF10
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
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Protein names
Recommended name:
Tumor necrosis factor ligand superfamily member 10Alternative name(s):
Apo-2 ligandApo-2L
TNF-related apoptosis-inducing ligand
Protein TRAIL
CD antigen CD253
- RS1131532 (TNFSF10) ??
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Top Gene-Substance Interactions
TNFSF10 Interacts with These Diseases
| Disease | Score |
Substances That Increase TNFSF10
| Substances | Interaction | Organism | Category |
Substances That Decrease TNFSF10
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widespread; most predominant in spleen, lung and prostate.
Gene Pathways:
Cofactor:
Binds 1 zinc ion per trimer.
Molecular Function:
Biological Processes:
- Apoptotic Process
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Immune Response
- Signal Transduction
- Cell Surface Receptor Signaling Pathway
- Cell-Cell Signaling
- Male Gonad Development
- Response To Insulin
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Positive Regulation Of Release Of Cytochrome C From Mitochondria
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
- Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Positive Regulation Of Extrinsic Apoptotic Signaling Pathway