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  3. TNFSF10

TNFSF10 (Tumor necrosis factor superfamily member 10)

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The Function of TNFSF10

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

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Protein names

Recommended name:

Tumor necrosis factor ligand superfamily member 10

Alternative name(s):

Apo-2 ligand
Apo-2L
TNF-related apoptosis-inducing ligand
Protein TRAIL
CD antigen CD253

TNFSF10 SNPs

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  1. RS1131532 (TNFSF10) ??

Top Gene-Substance Interactions

TNFSF10 Interacts with These Diseases

Disease Score

Substances That Increase TNFSF10

Substances Interaction Organism Category

Substances That Decrease TNFSF10

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • Egr-1
  • IRF-1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • YY1

Tissue specificity:

Widespread; most predominant in spleen, lung and prostate.

Gene Pathways:

  • Cytokine-cytokine receptor interaction
  • Measles
  • Natural killer cell mediated cytotoxicity
  • Apoptosis
  • Apoptosis

Cofactor:

Binds 1 zinc ion per trimer.

Molecular Function:

  • Metal Ion Binding
  • Receptor Binding

Biological Processes:

  • Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
  • Apoptotic Process
  • Cell-Cell Signaling
  • Cell Surface Receptor Signaling Pathway
  • Immune Response
  • Male Gonad Development
  • Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Positive Regulation Of Release Of Cytochrome C From Mitochondria
  • Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
  • Response To Insulin
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_11986| apo2l| Apo-2L| Apo-2 ligand| AS27_14092| AS28_05309| CD253| chemokine tumor necrosis factor ligand superfamily member 10| DL2| I79_005932| Ly81| M959_12428| MDA_GLEAN10019623| N300_12646| N301_00581| N302_03705| N303_02740| N305_05403| N306_05016| N308_11085| N309_13106| N311_05824| N312_09227| N320_10902| N322_08141| N325_08391| N328_04397| N329_05727| N330_08178| N331_08278| N332_10816| N335_10523| N336_12147| PAL_GLEAN10012872| PANDA_010545| tl2| TNF-related apoptosis inducing ligand| TNF-related apoptosis-inducing ligand| TNF-related apoptosis inducing ligand TRAIL| TNFSF10-1| tnfsf10l2| TNLG6A| trail| trail1| TRAIL/APO2L| TREES_T100010081| tumor necrosis factor apoptosis-inducing ligand splice variant delta| tumor necrosis factor ligand 6a| tumor necrosis factor (ligand) family, member 10| tumor necrosis factor (ligand) superfamily, member 10| Tumor necrosis factor ligand superfamily member 10| tumor necrosis factor (ligand) superfamily, member 10 like 2| tumor necrosis factor-related apoptosis-inducing ligand| UY3_13822| xtrail1| Y1Q_009153| Y956_10190| Z169_10418| tnfsf10

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