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  3. TNFRSF21

TNFRSF21 (TNF receptor superfamily member 21)

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The Function of TNFRSF21

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.

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Protein names

Recommended name:

Tumor necrosis factor receptor superfamily member 21

Alternative name(s):

Death receptor 6
CD antigen CD358

TNFRSF21 SNPs

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  1. RS2103868 (TNFRSF21) ??

Top Gene-Substance Interactions

TNFRSF21 Interacts with These Diseases

Disease Score

Substances That Increase TNFRSF21

Substances Interaction Organism Category

Substances That Decrease TNFRSF21

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • IRF-1

Tissue specificity:

Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.

Gene Pathways:

  • Metabolism
  • Cytokine-cytokine receptor interaction

Induction:

Up-regulated by TNF.

Caution:

It is uncertain whether Met-1 or Met-25 is the initiator.

Molecular Function:

  • Tumor Necrosis Factor-Activated Receptor Activity

Biological Processes:

  • Adaptive Immune Response
  • Apoptotic Process
  • Apoptotic Signaling Pathway
  • B Cell Apoptotic Process
  • Cellular Response To Tumor Necrosis Factor
  • Humoral Immune Response
  • Immune Response
  • Inflammatory Response
  • Myelination
  • Negative Regulation Of B Cell Proliferation
  • Negative Regulation Of Interleukin-10 Secretion
  • Negative Regulation Of Interleukin-13 Secretion
  • Negative Regulation Of Interleukin-5 Secretion
  • Negative Regulation Of Myelination
  • Negative Regulation Of T Cell Proliferation
  • Neuron Apoptotic Process
  • Oligodendrocyte Apoptotic Process
  • Regulation Of Apoptotic Process
  • Regulation Of Cell Proliferation
  • Regulation Of Oligodendrocyte Differentiation
  • Response To Lipopolysaccharide
  • T Cell Receptor Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_11781| BM-018| CB1_001402122| CD358| D623_10026058| Death receptor 6| dr6| EGK_14978| GW7_08064| H920_02435| M91_05801| N308_10201| PAL_GLEAN10025351| PANDA_007622| R74815| TNFR-related death receptor 6| TNFR-related death receptor-6| TR7| TREES_T100007642| tumor necrosis factor receptor superfamily, member 21| Tumor necrosis factor receptor superfamily member 21| UY3_00625| Y1Q_028463| tnfrsf21

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