The Function of TNFRSF21
Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
Protein names
Recommended name:
Tumor necrosis factor receptor superfamily member 21Alternative name(s):
Death receptor 6CD antigen CD358
- RS2103868 (TNFRSF21) ??
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Top Gene-Substance Interactions
TNFRSF21 Interacts with These Diseases
| Disease | Score |
Substances That Increase TNFRSF21
| Substances | Interaction | Organism | Category |
Substances That Decrease TNFRSF21
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
Gene Pathways:
Induction:
Up-regulated by TNF.
Caution:
It is uncertain whether Met-1 or Met-25 is the initiator.
Molecular Function:
Biological Processes:
- B Cell Apoptotic Process
- Adaptive Immune Response
- Apoptotic Process
- Inflammatory Response
- Immune Response
- Humoral Immune Response
- Negative Regulation Of B Cell Proliferation
- Negative Regulation Of Myelination
- Response To Lipopolysaccharide
- Regulation Of Cell Proliferation
- Negative Regulation Of T Cell Proliferation
- Myelination
- Regulation Of Apoptotic Process
- Regulation Of Oligodendrocyte Differentiation
- T Cell Receptor Signaling Pathway
- Neuron Apoptotic Process
- Cellular Response To Tumor Necrosis Factor
- Apoptotic Signaling Pathway
- Oligodendrocyte Apoptotic Process
- Negative Regulation Of Interleukin-5 Secretion
- Negative Regulation Of Interleukin-13 Secretion
- Negative Regulation Of Interleukin-10 Secretion