Summary of TNFRSF1B
The three most common inflammatory cytokines that are responsible for chronic inflammatory diseases are Tumor Necrosis Factor (TNF), Interleukin-1beta (IL-1b) and Interleukin-6 (IL-6). TNF plays a major role in many diseases, including autoimmune diseases, heart disease, and cancer. TNF increases CRP, which is a common blood measurement to gauge inflammation.
The Function of TNFRSF1B
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Protein names
Recommended name:
Tumor necrosis factor receptor superfamily member 1BAlternative name(s):
Tumor necrosis factor receptor 2TNF-R2
Tumor necrosis factor receptor type II
TNF-RII
TNFR-II
p75
p80 TNF-alpha receptor
CD antigen CD120b
Etanercept
TBP-2
TBPII
- RS1061622 (TNFRSF1B) ??
- RS1061624 (TNFRSF1B) ??
- RS5746059 (TNFRSF1B) ??
- RS5746061 (TNFRSF1B) ??
- RS976881 (TNFRSF1B) ??
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Top Gene-Substance Interactions
TNFRSF1B Interacts with These Diseases
| Disease | Score |
Substances That Increase TNFRSF1B
| Substances | Interaction | Organism | Category |
Substances That Decrease TNFRSF1B
| Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: narcolepsy
From NCBI Gene: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008] From UniProt: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha . Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Inflammatory Response
- Immune Response
- Multicellular Organism Development
- Aging
- Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
- Tumor Necrosis Factor-Mediated Signaling Pathway
- Regulation Of Cell Proliferation
- Regulation Of Apoptotic Process
- Positive Regulation Of Mapk Cascade
- Negative Regulation Of Inflammatory Response
- Rna Destabilization
- Positive Regulation Of Membrane Protein Ectodomain Proteolysis
- Cellular Response To Lipopolysaccharide
- Cellular Response To Growth Factor Stimulus
- Apoptotic Signaling Pathway
- Extrinsic Apoptotic Signaling Pathway
Drug Bank:
- Etanercept