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  3. TNFRSF1B

TNFRSF1B (TNF receptor superfamily member 1B)

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Summary of TNFRSF1B

The three most common inflammatory cytokines that are responsible for chronic inflammatory diseases are Tumor Necrosis Factor (TNF), Interleukin-1beta (IL-1b) and Interleukin-6 (IL-6). TNF plays a major role in many diseases, including autoimmune diseases, heart disease, and cancer. TNF increases CRP, which is a common blood measurement to gauge inflammation.

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The Function of TNFRSF1B

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Protein names

Recommended name:

Tumor necrosis factor receptor superfamily member 1B

Alternative name(s):

Tumor necrosis factor receptor 2
TNF-R2
Tumor necrosis factor receptor type II
TNF-RII
TNFR-II
p75
p80 TNF-alpha receptor
CD antigen CD120b
Etanercept
TBP-2
TBPII

TNFRSF1B SNPs

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  1. RS1061622 (TNFRSF1B) ??
  2. RS1061624 (TNFRSF1B) ??
  3. RS5746059 (TNFRSF1B) ??
  4. RS5746061 (TNFRSF1B) ??
  5. RS976881 (TNFRSF1B) ??

Top Gene-Substance Interactions

TNFRSF1B Interacts with These Diseases

Disease Score

Substances That Increase TNFRSF1B

Substances Interaction Organism Category

Substances That Decrease TNFRSF1B

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: narcolepsy

     From NCBI Gene: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008] From UniProt: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha . Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • CUTL1
  • Egr-1
  • AP-1
  • c-Jun
  • NF-kappaB1
  • AML1a

Gene Pathways:

  • Adipocytokine signaling pathway
  • Cytokine-cytokine receptor interaction
  • Amyotrophic lateral sclerosis (ALS)

Molecular Function:

  • Tumor Necrosis Factor-Activated Receptor Activity
  • Ubiquitin Protein Ligase Binding

Biological Processes:

  • Aging
  • Apoptotic Signaling Pathway
  • Cellular Response To Growth Factor Stimulus
  • Cellular Response To Lipopolysaccharide
  • Extrinsic Apoptotic Signaling Pathway
  • Immune Response
  • Inflammatory Response
  • Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
  • Multicellular Organism Development
  • Negative Regulation Of Inflammatory Response
  • Positive Regulation Of Mapk Cascade
  • Positive Regulation Of Membrane Protein Ectodomain Proteolysis
  • Regulation Of Apoptotic Process
  • Regulation Of Cell Proliferation
  • Rna Destabilization
  • Tumor Necrosis Factor-Mediated Signaling Pathway

Drug Bank:

  • Etanercept
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| p75| rank| TNF-R2| A306_13106| AS27_12970| AS28_08748| CB1_001783016| CD120b| D623_10022032| H920_06999| I79_024559| M91_08664| M959_03288| MDA_GLEAN10024358| N301_14180| N303_02603| N306_05310| N307_01423| N308_08282| N309_10638| N312_03182| N321_05371| N322_08394| N326_08121| N329_09736| N330_00416| N331_11078| N333_13290| N335_11070| N336_08489| N340_10824| N341_09545| p75TNFR| p75 TNFR| p75 TNF receptor| p75 tumor necrosis factor membrane receptor| p80 TNF-alpha receptor| PAL_GLEAN10012978| PANDA_011827| soluble TNFR1B variant 1| TBPII| TNF-alphaR2| TNFalpha-R2| TNFBR| Tnfr-1| TNFR1B| Tnfr2| TNF-R75| TNFR80| TNF receptor beta chain| TNFRII| TNF-RII| TNF-R-II| TNFR-II| TNF-RII/TNFRSF1B| TREES_T100008730| tumor necrosis factor beta receptor| tumor necrosis factor binding protein 2| tumor necrosis factor receptor 2| tumor necrosis factor receptor-II| tumor necrosis factor receptor superfamily, member 1b| tumor necrosis factor receptor superfamily member 1B| tumor necrosis factor receptor type II| tumour necrosis factor receptor p80| Y1Q_012024| Y956_10756| tnfrsf1b

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