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  3. TNFRSF14

TNFRSF14 (TNF receptor superfamily member 14)

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The Function of TNFRSF14

(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2.

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Protein names

Recommended name:

Tumor necrosis factor receptor superfamily member 14

Short name:

TR2

Alternative name(s):

Herpes virus entry mediator A
Herpesvirus entry mediator A
HveA
Tumor necrosis factor receptor-like 2
CD antigen CD270

Top Gene-Substance Interactions

TNFRSF14 Interacts with These Diseases

Disease Score

Substances That Increase TNFRSF14

Substances Interaction Organism Category

Substances That Decrease TNFRSF14

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • Arnt
  • NF-kappaB1
  • c-Myc
  • GATA-1
  • ITF-2
  • Tal-1beta
  • NF-kappaB2

Tissue specificity:

Widely expressed, with the highest expression in lung, spleen and thymus.

Gene Pathways:

  • Immune System
  • Cytokine-cytokine receptor interaction

Molecular Function:

  • Tumor Necrosis Factor-Activated Receptor Activity
  • Ubiquitin Protein Ligase Binding
  • Virus Receptor Activity

Biological Processes:

  • Apoptotic Signaling Pathway
  • Cell Surface Receptor Signaling Pathway
  • Defense Response To Gram-Negative Bacterium
  • Defense Response To Gram-Positive Bacterium
  • Immune Response
  • Inflammatory Response
  • Multicellular Organism Development
  • Negative Regulation Of Alpha-Beta T Cell Proliferation
  • Positive Regulation Of Cytokine Secretion Involved In Immune Response
  • Positive Regulation Of Mapk Cascade
  • Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
  • Positive Regulation Of T Cell Migration
  • Regulation Of Apoptotic Process
  • Regulation Of Cell Proliferation
  • Response To Lipopolysaccharide
  • T Cell Costimulation
  • Tumor Necrosis Factor-Mediated Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_13212| Atar| CD270| CD40-like protein| ELR1| herpes virus entry mediator| herpes virus entry mediator A| herpesvirus entry mediator A| HVEA| HVEM| I79_022919| lentivirus receptor 1| LIGHTR| MDA_GLEAN10000149| PANDA_013752| TNF-R2| Tnfrs14| TR2| tumor necrosis factor receptor-like gene2| tumor necrosis factor receptor superfamily member| tumor necrosis factor receptor superfamily member 14| tumor necrosis factor receptor superfamily, member 14| tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)| tumor necrosis factor receptor superfamily member 16-like| Tumor necrosis factor receptor superfamily member 6| tnfrsf14

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