The Function of TNFRSF14
(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2.
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Protein names
Recommended name:
Tumor necrosis factor receptor superfamily member 14Short name:
TR2Alternative name(s):
Herpes virus entry mediator AHerpesvirus entry mediator A
HveA
Tumor necrosis factor receptor-like 2
CD antigen CD270
Top Gene-Substance Interactions
TNFRSF14 Interacts with These Diseases
| Disease | Score |
Substances That Increase TNFRSF14
| Substances | Interaction | Organism | Category |
Substances That Decrease TNFRSF14
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed, with the highest expression in lung, spleen and thymus.
Gene Pathways:
Molecular Function:
- Tumor Necrosis Factor-Activated Receptor Activity
- Ubiquitin Protein Ligase Binding
- Virus Receptor Activity
Biological Processes:
- Apoptotic Signaling Pathway
- Cell Surface Receptor Signaling Pathway
- Defense Response To Gram-Negative Bacterium
- Defense Response To Gram-Positive Bacterium
- Immune Response
- Inflammatory Response
- Multicellular Organism Development
- Negative Regulation Of Alpha-Beta T Cell Proliferation
- Positive Regulation Of Cytokine Secretion Involved In Immune Response
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Positive Regulation Of T Cell Migration
- Regulation Of Apoptotic Process
- Regulation Of Cell Proliferation
- Response To Lipopolysaccharide
- T Cell Costimulation
- Tumor Necrosis Factor-Mediated Signaling Pathway