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  3. TNFAIP8

TNFAIP8 (TNF alpha induced protein 8)

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The Function of TNFAIP8

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

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Protein names

Recommended name:

Tumor necrosis factor alpha-induced protein 8

Short name:

NDED

Alternative name(s):

TNF alpha-induced protein 8
Head and neck tumor and metastasis-related protein
MDC-3.13
NF-kappa-B-inducible DED-containing protein
SCC-S2
TNF-induced protein GG2-1

TNFAIP8 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1032859 (TNFAIP8) ??
  2. RS1045241 (TNFAIP8) ??

Top Gene-Substance Interactions

TNFAIP8 Interacts with These Diseases

Disease Score

Substances That Increase TNFAIP8

Substances Interaction Organism Category

Substances That Decrease TNFAIP8

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • C/EBPalpha
  • E4BP4
  • E47
  • HFH-1
  • Hand1

Tissue specificity:

Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.

Induction:

By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.

Developmental stage:

Expressed at high levels in the fetal liver, lung and kidney.

Molecular Function:

  • Cysteine-Type Endopeptidase Inhibitor Activity Involved In Apoptotic Process

Biological Processes:

  • Negative Regulation Of Apoptotic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_03753| Anapl_15868| AS27_15945| AS28_04525| CB1_000244004| EGK_16774| ENSMUSG00000073567| Gg2-1| GW7_07528| H920_09451| head and neck tumor and metastasis-related protein| M91_07286| M959_09001| MDA_GLEAN10021749| MDC-3.13| N300_12767| N301_02899| N302_15684| N303_04803| N305_10226| N306_13648| N307_01387| N308_00632| N309_11252| N310_12976| N311_04536| N312_10317| N320_13236| N321_08278| N322_11737| N324_12483| N325_09050| N326_11163| N327_12567| N328_01897| N329_03140| N330_03403| N331_10883| N332_12605| N333_07697| N334_01057| N335_08557| N336_09715| N339_12568| N340_12320| N341_03922| Nded| NF-kappa-B-inducible DED-containing protein| PAL_GLEAN10025063| PANDA_003494| SCCS2| SCC-S2| Ssc-2| Tipe| TNF alpha-induced protein 8| TNF-induced protein| TNF-induced protein GG2-1| tumor necrosis factor alpha-induced protein 8| tumor necrosis factor, alpha induced protein 8| tumor necrosis factor, alpha-induced protein 8| tumor necrosis factor alpha-induced protein 8-like protein| tumor necrosis factor alpha-induced protein 8-like protein 2-like protein| tumor necrosis factor, alpha-induced protein-like protein| UY3_16795| Y1Q_015632| Y956_12592| Z169_06277| tnfaip8

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