The Function of TNFAIP8
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Protein names
Recommended name:
Tumor necrosis factor alpha-induced protein 8Short name:
NDEDAlternative name(s):
TNF alpha-induced protein 8Head and neck tumor and metastasis-related protein
MDC-3.13
NF-kappa-B-inducible DED-containing protein
SCC-S2
TNF-induced protein GG2-1
- RS1032859 (TNFAIP8) ??
- RS1045241 (TNFAIP8) ??
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Top Gene-Substance Interactions
TNFAIP8 Interacts with These Diseases
| Disease | Score |
Substances That Increase TNFAIP8
| Substances | Interaction | Organism | Category |
Substances That Decrease TNFAIP8
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.
Induction:
By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.
Developmental stage:
Expressed at high levels in the fetal liver, lung and kidney.