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  3. TNC

TNC (Tenascin C)

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The Function of TNC

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.

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Protein names

Recommended name:

Tenascin

Short name:

TN

Alternative name(s):

Cytotactin
GMEM
GP 150-225
Glioma-associated-extracellular matrix antigen
Hexabrachion
JI
Myotendinous antigen
Neuronectin
Tenascin-C
TN-C

TNC SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1888221 (TNC) ??
  2. RS200384196 (TNC) ??
  3. RS2104772 (TNC) ??
  4. RS7847271 (TNC) ??

Top Gene-Substance Interactions

TNC Interacts with These Diseases

Disease Score

Substances That Increase TNC

Substances Interaction Organism Category

Substances That Decrease TNC

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • STAT3
  • NF-kappaB1
  • Sp1

Gene Pathways:

  • Extracellular matrix organization

Induction:

By TGFB1.

Molecular Function:

  • Syndecan Binding

Biological Processes:

  • Bud Outgrowth Involved In Lung Branching
  • Cell Adhesion
  • Cellular Response To Prostaglandin D Stimulus
  • Cellular Response To Retinoic Acid
  • Cellular Response To Vitamin D
  • Extracellular Matrix Organization
  • Mesenchymal-Epithelial Cell Signaling Involved In Prostate Gland Development
  • Negative Regulation Of Cell Adhesion
  • Neuromuscular Junction Development
  • Odontogenesis Of Dentin-Containing Tooth
  • Osteoblast Differentiation
  • Peripheral Nervous System Axon Regeneration
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Gene Expression
  • Prostate Gland Epithelium Morphogenesis
  • Response To Ethanol
  • Response To Fibroblast Growth Factor
  • Response To Mechanical Stimulus
  • Response To Wounding
  • Wound Healing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| TN| Tenascin-R| GP| 150-225| A306_06080| AS27_09049| AS28_06675| CB1_000869017| CG13648 gene product from transcript CG13648-RD| CG13648-PC| CG13648-PD| cytotactin| D623_10028461| deafness, autosomal dominant 56| DFNA56| Dmel_CG13648| etID309720.5| glioma-associated-extracellular matrix antigen| GMEM| GP 150-225| GW7_01799| H920_11882| hexabrachion| hexabrachion (tenascin)| HXB| I79_013794| JI| M91_17266| M959_02292| MDA_GLEAN10014436| mucin related 96B| Mur96B| myotendinous antigen| N300_07970| N301_12778| N302_08369| N303_06058| N305_07776| N306_07860| N307_12586| N309_02755| N311_08746| N312_12365| N322_00709| N324_03448| N326_13414| N327_13139| N332_14649| N333_12081| N334_03505| N336_12488| N339_12598| neuronectin| P230| PAL_GLEAN10009830| PANDA_003833| Ten| Tenascin| tenascin-C| tenascin-C AD1 domain| tenascin-C additional domain 1| tenascin C (hexabrachion)| tenascin-C isoform 14/AD1/16| tenc| tenectin| TN-C| Tn-C AD1| tnc-PC| tnc-PD| TREES_T100003780| UY3_04675| Y1Q_024617| Y956_15859| tnc

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