The Function of TNC
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
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Protein names
Recommended name:
TenascinShort name:
TNAlternative name(s):
CytotactinGMEM
GP 150-225
Glioma-associated-extracellular matrix antigen
Hexabrachion
JI
Myotendinous antigen
Neuronectin
Tenascin-C
TN-C
- RS1888221 (TNC) ??
- RS200384196 (TNC) ??
- RS2104772 (TNC) ??
- RS7847271 (TNC) ??
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Top Gene-Substance Interactions
TNC Interacts with These Diseases
| Disease | Score |
Substances That Increase TNC
| Substances | Interaction | Organism | Category |
Substances That Decrease TNC
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By TGFB1.
Molecular Function:
Biological Processes:
- Osteoblast Differentiation
- Cell Adhesion
- Negative Regulation Of Cell Adhesion
- Neuromuscular Junction Development
- Positive Regulation Of Cell Proliferation
- Response To Wounding
- Response To Mechanical Stimulus
- Positive Regulation Of Gene Expression
- Peripheral Nervous System Axon Regeneration
- Extracellular Matrix Organization
- Wound Healing
- Odontogenesis Of Dentin-Containing Tooth
- Response To Ethanol
- Bud Outgrowth Involved In Lung Branching
- Mesenchymal-Epithelial Cell Signaling Involved In Prostate Gland Development
- Prostate Gland Epithelium Morphogenesis
- Cellular Response To Retinoic Acid
- Cellular Response To Vitamin D
- Response To Fibroblast Growth Factor
- Cellular Response To Prostaglandin D Stimulus