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  3. TMPRSS2

TMPRSS2 (Transmembrane protease, serine 2)

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The Function of TMPRSS2

Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

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Protein names

Recommended name:

Transmembrane protease serine 2

Alternative name(s):

Serine protease 10

TMPRSS2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1041449 (TMPRSS2) ??
  2. RS12329760 (TMPRSS2) ??
  3. RS183026840 (TMPRSS2) ??

Top Gene-Substance Interactions

TMPRSS2 Interacts with These Diseases

Disease Score

Substances That Increase TMPRSS2

Substances Interaction Organism Category

Substances That Decrease TMPRSS2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO3
  • FOXO3a
  • FOXO4
  • FOXO1a
  • FOXF2
  • FOXO1
  • AREB6
  • Gfi-1

Tissue specificity:

Highly expressed in prostate epithelial cells and in prostate cancers. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland.

Molecular Function:

  • Scavenger Receptor Activity
  • Serine-Type Endopeptidase Activity
  • Serine-Type Peptidase Activity

Biological Processes:

  • Positive Regulation Of Viral Entry Into Host Cell
  • Protein Autoprocessing
  • Proteolysis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_00568| Anapl_13351| AS27_04888| AS28_02963| CB1_000081002| D16Ertd61e| epitheliasin| GW7_10196| I79_009287| M91_11735| M959_05793| MDA_GLEAN10011724| N300_11121| N301_07353| N302_10434| N303_14952| N305_03960| N306_09217| N307_05585| N308_06015| N309_13506| N310_12726| N311_12333| N312_02705| N320_03950| N322_00464| N324_02527| N325_00953| N326_13187| N327_07042| N328_12915| N330_00798| N331_04602| N332_01080| N333_02892| N334_14317| N336_11751| N339_08780| N340_13877| PANDA_015502| plasmic transmembrane protein X| pp9284| prss10| serine protease 10| Transmembrane protease serine 2| TREES_T100017909| UY3_11380| Xesp-2| Y1Q_014489| Y956_04437| Z169_11017| tmprss2

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