The Function of TMOD1
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.
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Protein names
Recommended name:
Tropomodulin-1Alternative name(s):
Erythrocyte tropomodulinE-Tmod
- RS139475366 (TMOD1) ??
- RS1475545 (TMOD1) ??
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Top Gene-Substance Interactions
TMOD1 Interacts with These Diseases
| Disease | Score |
Substances That Increase TMOD1
| Substances | Interaction | Organism | Category |
Substances That Decrease TMOD1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in the erythrocyte, heart and skeletal muscle.
Gene Pathways:
Molecular Function:
Biological Processes:
- Actin Filament Organization
- Adult Locomotory Behavior
- Lens Fiber Cell Development
- Muscle Contraction
- Muscle Filament Sliding
- Myofibril Assembly
- Pointed-End Actin Filament Capping