The Function of TMEM129
E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.
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Protein names
Recommended name:
E3 ubiquitin-protein ligase TM129Top Gene-Substance Interactions
Substances That Increase TMEM129
| Substances | Interaction | Organism | Category |
Substances That Decrease TMEM129
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Er-Associated Ubiquitin-Dependent Protein Catabolic Process
- Protein Polyubiquitination
- Response To Unfolded Protein
- Retrograde Protein Transport, Er To Cytosol