The Function of TMEFF2
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
Protein names
Recommended name:
Tomoregulin-2Short name:
TR-2Alternative name(s):
Hyperplastic polyposis protein 1Transmembrane protein with EGF-like and two follistatin-like domains
- RS10497721 (TMEFF2) ??
- RS1113932 (TMEFF2) ??
- RS13007495 (TMEFF2) ??
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Top Gene-Substance Interactions
TMEFF2 Interacts with These Diseases
| Disease | Score |
Substances That Increase TMEFF2
| Substances | Interaction | Organism | Category |
Substances That Decrease TMEFF2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.
Induction:
Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines.
Biological Processes:
- Negative Regulation Of Cell Migration
- Wound Healing, Spreading Of Cells
- Negative Regulation Of Integrin Biosynthetic Process
- Negative Regulation Of Stress Fiber Assembly