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  3. TMEFF2

TMEFF2 (Transmembrane protein with EGF like and two follistatin like domains 2)

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The Function of TMEFF2

May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.

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Protein names

Recommended name:

Tomoregulin-2

Short name:

TR-2

Alternative name(s):

Hyperplastic polyposis protein 1
Transmembrane protein with EGF-like and two follistatin-like domains

TMEFF2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10497721 (TMEFF2) ??
  2. RS1113932 (TMEFF2) ??
  3. RS13007495 (TMEFF2) ??

Top Gene-Substance Interactions

TMEFF2 Interacts with These Diseases

Disease Score

Substances That Increase TMEFF2

Substances Interaction Organism Category

Substances That Decrease TMEFF2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • c-Myc
  • Sp1
  • Nkx3-1 v1
  • Nkx3-1

Tissue specificity:

Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.

Induction:

Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines.

Biological Processes:

  • Negative Regulation Of Cell Migration
  • Negative Regulation Of Integrin Biosynthetic Process
  • Negative Regulation Of Stress Fiber Assembly
  • Wound Healing, Spreading Of Cells
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| TR| A306_12968| Anapl_16477| AS27_02191| AS28_06087| cancer/testis antigen family 120, member 2| CB1_000931001| CT120.2| D623_10016065| EGK_04638| EH28_24944| H920_10666| HPP1| hyperplastic polyposis protein 1| I79_020504| M91_04603| M959_07784| MDA_GLEAN10023662| N300_08065| N301_02412| N302_09831| N303_01639| N306_11850| N307_08539| N308_09518| N309_14562| N310_07646| N312_04161| N324_01550| N326_03179| N327_06521| N330_11337| N331_08900| PAL_GLEAN10026078| PANDA_006426| TENB2| tomoregulin| Tomoregulin-2| tomoregulin-2-like protein| tpef| TR-2| transmembrane protein TENB2| transmembrane protein with EGF-like and two follistatin-like dom| transmembrane protein with EGF-like and two follistatin-like domains| transmembrane protein with EGF-like and two follistatin-like domains 2| UY3_16656| Y956_03971| Z169_07069| tmeff2

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