The Function of TMCO1
Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (PubMed:27212239).
Protein names
Recommended name:
Calcium load-activated calcium channelAlternative name(s):
CLAC channelTransmembrane and coiled-coil domain-containing protein 1
Transmembrane and coiled-coil domains protein 4
Xenogeneic cross-immune protein PCIA3
- RS4656461 (TMCO1) ??
- RS7518099 (TMCO1) ??
- RS7555523 (TMCO1) ??
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Top Gene-Substance Interactions
TMCO1 Interacts with These Diseases
| Disease | Score |
Substances That Increase TMCO1
| Substances | Interaction | Organism | Category |
Substances That Decrease TMCO1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed in adult and fetal tissues, with higher levels in thymus, prostate, testis and small intestine and lower levels in brain, placenta, lung and kidney (PubMed:10393320, PubMed:20018682). Present in most tissues in the eye, including the trabecular meshwork and retina (at protein level) (PubMed:22714896).
Molecular Function:
Biological Processes:
- Er Overload Response
- Endoplasmic Reticulum Calcium Ion Homeostasis
- Calcium Ion Transmembrane Transport