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  3. TMCO1

TMCO1 (Transmembrane and coiled-coil domains 1)

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The Function of TMCO1

Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (PubMed:27212239).

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Protein names

Recommended name:

Calcium load-activated calcium channel

Alternative name(s):

CLAC channel
Transmembrane and coiled-coil domain-containing protein 1
Transmembrane and coiled-coil domains protein 4
Xenogeneic cross-immune protein PCIA3

TMCO1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4656461 (TMCO1) ??
  2. RS7518099 (TMCO1) ??
  3. RS7555523 (TMCO1) ??

Top Gene-Substance Interactions

TMCO1 Interacts with These Diseases

Disease Score

Substances That Increase TMCO1

Substances Interaction Organism Category

Substances That Decrease TMCO1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AhR
  • STAT3
  • PPAR-alpha
  • NRF-2
  • NF-AT4
  • NF-AT3
  • NF-AT2

Tissue specificity:

Widely expressed in adult and fetal tissues, with higher levels in thymus, prostate, testis and small intestine and lower levels in brain, placenta, lung and kidney (PubMed:10393320, PubMed:20018682). Present in most tissues in the eye, including the trabecular meshwork and retina (at protein level) (PubMed:22714896).

Molecular Function:

  • Calcium Channel Activity

Biological Processes:

  • Calcium Ion Transmembrane Transport
  • Endoplasmic Reticulum Calcium Ion Homeostasis
  • Er Overload Response
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_10595| AS27_15729| AS28_09950| calcium load-activated calcium channel| CLAC channel| EGK_01911| ESTM39| GW7_21151| H920_09469| HP10122| I79_012756| M959_08675| meg-2-like protein| N300_10207| N301_09682| N302_00495| N303_07916| N305_07602| N306_01378| N307_04705| N308_02217| N309_08512| N310_01509| N311_01034| N312_03685| N320_03465| N321_09471| N322_08550| N324_10846| N325_08077| N328_10951| N329_10377| N330_09183| N331_03404| N333_11818| N335_12012| N336_10082| N339_06054| N340_06056| N341_06501| PAL_GLEAN10017875| PANDA_002089| PCIA3| PNAS-136| putative membrane protein| TMCC4| transmembrane and coiled-coil domain-containing 1-like protein| Transmembrane and coiled-coil domain-containing protein 1| transmembrane and coiled-coil domains 4| transmembrane and coiled-coil domains protein 1| transmembrane and coiled-coil domains protein 1-like| TREES_T100015688| xenogeneic cross-immune protein PCIA3| Y1Q_022931| Y956_03429| Z169_13443| tmco1

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