Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

     Covered on Genetics Home Reference: systemic lupus erythematosusFrom NCBI Gene: Systemic lupus erythematosus 1Melioidosis, susceptibility toLegionellosisFrom UniProt: Systemic lupus erythematosus 1 (SLEB1): A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. [MIM:601744]

     From NCBI Gene: This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009] From UniProt: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• NF-kappaB
• AP-1
• c-Jun
• NF-kappaB1
• c-Myc
• c-Fos
• IRF-1

Tissue specificity:

Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.

Molecular Function:

• Interleukin-1 Receptor Binding
• Receptor Activity
• Transmembrane Signaling Receptor Activity

Biological Processes:

• Cellular Response To Lipopolysaccharide
• Cellular Response To Mechanical Stimulus
• Defense Response To Gram-Negative Bacterium
• Inflammatory Response
• Innate Immune Response
• Male Gonad Development
• Myd88-Dependent Toll-Like Receptor Signaling Pathway
• Positive Regulation Of Interleukin-8 Production
• Positive Regulation Of Nitric Oxide Biosynthetic Process
• Positive Regulation Of Toll-Like Receptor Signaling Pathway
• Regulation Of Cytokine Secretion
• Toll-Like Receptor 5 Signaling Pathway

*synonyms