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  3. TLR5

TLR5 (Toll like receptor 5)

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The Function of TLR5

Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

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Protein names

Recommended name:

Toll-like receptor 5

Alternative name(s):

Toll/interleukin-1 receptor-like protein 3

TLR5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2072493 (TLR5) ??
  2. RS5744168 (TLR5) ??
  3. RS5744174 (TLR5) ??

Top Gene-Substance Interactions

TLR5 Interacts with These Diseases

Disease Score

Substances That Increase TLR5

Substances Interaction Organism Category

Substances That Decrease TLR5

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: systemic lupus erythematosusFrom NCBI Gene: Systemic lupus erythematosus 1Melioidosis, susceptibility toLegionellosisFrom UniProt: Systemic lupus erythematosus 1 (SLEB1): A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. [MIM:601744]

     From NCBI Gene: This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009] From UniProt: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • c-Myc
  • c-Fos
  • IRF-1

Tissue specificity:

Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.

Gene Pathways:

  • Immune System
  • Toll-like receptor signaling pathway
  • Pathogenic Escherichia coli infection

Molecular Function:

  • Interleukin-1 Receptor Binding
  • Receptor Activity
  • Transmembrane Signaling Receptor Activity

Biological Processes:

  • Cellular Response To Lipopolysaccharide
  • Cellular Response To Mechanical Stimulus
  • Defense Response To Gram-Negative Bacterium
  • Inflammatory Response
  • Innate Immune Response
  • Male Gonad Development
  • Myd88-Dependent Toll-Like Receptor Signaling Pathway
  • Positive Regulation Of Interleukin-8 Production
  • Positive Regulation Of Nitric Oxide Biosynthetic Process
  • Positive Regulation Of Toll-Like Receptor Signaling Pathway
  • Regulation Of Cytokine Secretion
  • Toll-Like Receptor 5 Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_00329| CB1_001073052| GW7_19645| H920_13139| I79_000060| MDA_GLEAN10022846| MELIOS| membrane toll-like receptor 5| N302_00752| N307_10417| N309_03709| N312_09475| N321_02164| PAL_GLEAN10012145| PANDA_011408| SLE1| SLEB1| susd4| sushi domain containing 4| sushi domain-containing protein 4| systemic lupus erythematosus susceptibility 1| TIL3| TLR 5| TLR-5| toll/interleukin-1 receptor-like protein 3| toll-like receptor 5| TREES_T100015517| UY3_17196| Y1Q_027052| tlr5

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