The Function of TLR5
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Protein names
Recommended name:
Toll-like receptor 5Alternative name(s):
Toll/interleukin-1 receptor-like protein 3- RS2072493 (TLR5) ??
- RS5744168 (TLR5) ??
- RS5744174 (TLR5) ??
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Top Gene-Substance Interactions
TLR5 Interacts with These Diseases
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Substances That Increase TLR5
Substances | Interaction | Organism | Category |
Substances That Decrease TLR5
Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: systemic lupus erythematosusFrom NCBI Gene: Systemic lupus erythematosus 1Melioidosis, susceptibility toLegionellosisFrom UniProt: Systemic lupus erythematosus 1 (SLEB1): A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. [MIM:601744]
From NCBI Gene: This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009] From UniProt: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.
Gene Pathways:
Molecular Function:
Biological Processes:
- Cellular Response To Lipopolysaccharide
- Cellular Response To Mechanical Stimulus
- Defense Response To Gram-Negative Bacterium
- Inflammatory Response
- Innate Immune Response
- Male Gonad Development
- Myd88-Dependent Toll-Like Receptor Signaling Pathway
- Positive Regulation Of Interleukin-8 Production
- Positive Regulation Of Nitric Oxide Biosynthetic Process
- Positive Regulation Of Toll-Like Receptor Signaling Pathway
- Regulation Of Cytokine Secretion
- Toll-Like Receptor 5 Signaling Pathway