Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

TLR2 encodes a protein that is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It also promotes cell death in response to bacterial lipoproteins (R). 

It is associated with leprosy and tuberculosis (R). 

     From NCBI Gene: Leprosy 3Mycobacterium tuberculosis, susceptibility to

     From NCBI Gene: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] From UniProt: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PhoS1 (pstS1), some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36).The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211).

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• NF-kappaB
• PPAR-gamma1
• PPAR-gamma2
• AP-1
• c-Jun
• NF-kappaB1
• Sp1
• STAT1
• STAT1beta
• STAT1alpha

Tissue specificity:

Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.

Molecular Function:

• Lipopolysaccharide Binding
• Lipopolysaccharide Receptor Activity
• Peptidoglycan Binding
• Protein Heterodimerization Activity
• Receptor Activity
• Signaling Pattern Recognition Receptor Activity
• Toll-Like Receptor Binding
• Transmembrane Signaling Receptor Activity
• Triacyl Lipopeptide Binding

Biological Processes:

• Apoptotic Process
• Cellular Response To Bacterial Lipopeptide
• Cellular Response To Diacyl Bacterial Lipopeptide
• Cellular Response To Lipoteichoic Acid
• Cellular Response To Triacyl Bacterial Lipopeptide
• Central Nervous System Myelin Formation
• Cytokine Secretion Involved In Immune Response
• Defense Response To Gram-Positive Bacterium
• Detection Of Diacyl Bacterial Lipopeptide
• Detection Of Triacyl Bacterial Lipopeptide
• I-Kappab Phosphorylation
• Immune Response
• Inflammatory Response
• Innate Immune Response
• Interleukin-10 Production
• Leukotriene Metabolic Process
• Microglial Cell Activation
• Myd88-Dependent Toll-Like Receptor Signaling Pathway
• Negative Regulation Of Cell Proliferation
• Nitric Oxide Metabolic Process
• Positive Regulation Of Chemokine Production
• Positive Regulation Of Gene Expression
• Positive Regulation Of Inflammatory Response
• Positive Regulation Of Interferon-Beta Production
• Positive Regulation Of Interleukin-10 Production
• Positive Regulation Of Interleukin-12 Production
• Positive Regulation Of Interleukin-18 Production
• Positive Regulation Of Interleukin-6 Production
• Positive Regulation Of Interleukin-8 Production
• Positive Regulation Of Nf-Kappab Import Into Nucleus
• Positive Regulation Of Nf-Kappab Transcription Factor Activity
• Positive Regulation Of Nitric-Oxide Synthase Biosynthetic Process
• Positive Regulation Of Oligodendrocyte Differentiation
• Positive Regulation Of Toll-Like Receptor Signaling Pathway
• Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
• Positive Regulation Of Tumor Necrosis Factor Production
• Positive Regulation Of Wnt Signaling Pathway
• Regulation Of Cytokine Secretion
• Response To Fatty Acid
• Response To Hypoxia
• Response To Insulin
• Response To Progesterone
• Response To Toxic Substance
• Signal Transduction
• Toll-Like Receptor 2 Signaling Pathway
• Toll-Like Receptor Tlr1:Tlr2 Signaling Pathway
• Toll-Like Receptor Tlr6:Tlr2 Signaling Pathway

Drug Bank:

• Ospa Lipoprotein

*synonyms