• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. TLK1

TLK1 (Tousled like kinase 1)

Loading...

The Function of TLK1

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Serine/threonine-protein kinase tousled-like 1

Alternative name(s):

PKU-beta
Tousled-like kinase 1

TLK1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10183486 (TLK1) ??

Top Gene-Substance Interactions

Substances That Increase TLK1

Substances Interaction Organism Category

Substances That Decrease TLK1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Pbx1a
  • MRF-2
  • GATA-1
  • YY1
  • NF-AT4
  • NF-AT3
  • NF-AT2

Tissue specificity:

Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.

Enzyme Regulation:

Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation at Ser-743, potentially by CHEK1.

Molecular Function:

  • Atp Binding
  • Protein Serine/Threonine Kinase Activity

Biological Processes:

  • Cell Cycle
  • Cellular Response To Dna Damage Stimulus
  • Covalent Chromatin Modification
  • Intracellular Protein Transport
  • Intracellular Signal Transduction
  • Protein Phosphorylation
  • Regulation Of Chromatin Assembly Or Disassembly
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_07545| AS27_06860| AS28_00633| CB1_001160003| EH28_22274| GW7_20409| H920_16189| M959_07173| MDA_GLEAN10024267| N300_04561| N301_03087| N302_06771| N303_07218| N305_06608| N306_04062| N307_07562| N308_13171| N309_05345| N310_07270| N311_01392| N312_03845| N320_08864| N321_12546| N322_13800| N324_09518| N326_04226| N328_08041| N329_01280| N331_02836| N333_12582| N335_01722| N336_03416| N339_12378| N340_14142| PAL_GLEAN10025955| PKU-beta| serine threonine protein kinase| serine/threonine-protein kinase tousled-like 1| SNARE protein kinase SNAK| tousled-like kinase 1| TREES_T100016610| UY3_03996| Y1Q_031837| Y956_02256| Z169_02842| tlk1

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved