The Function of TLK1
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
Protein names
Recommended name:
Serine/threonine-protein kinase tousled-like 1Alternative name(s):
PKU-betaTousled-like kinase 1
- RS10183486 (TLK1) ??
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Top Gene-Substance Interactions
Substances That Increase TLK1
| Substances | Interaction | Organism | Category |
Substances That Decrease TLK1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.
Enzyme Regulation:
Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation at Ser-743, potentially by CHEK1.
Molecular Function:
Biological Processes:
- Regulation Of Chromatin Assembly Or Disassembly
- Protein Phosphorylation
- Intracellular Protein Transport
- Cellular Response To Dna Damage Stimulus
- Cell Cycle
- Covalent Chromatin Modification
- Intracellular Signal Transduction