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  3. TLE4

TLE4 (Transducin like enhancer of split 4)

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The Function of TLE4

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression.

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Protein names

Recommended name:

Transducin-like enhancer protein 4

Alternative name(s):

Grg-4
Groucho-related protein 4

TLE4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS13292136 (TLE4) ??
  2. RS13293121 (TLE4) ??
  3. RS17791483 (TLE4) ??
  4. RS17791513 (TLE4) ??
  5. RS914715 (TLE4) ??

Top Gene-Substance Interactions

TLE4 Interacts with These Diseases

Disease Score

Substances That Increase TLE4

Substances Interaction Organism Category

Substances That Decrease TLE4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Sp1
  • Pax-2
  • Pax-2b

Tissue specificity:

In all tissues examined, mostly in brain, and muscle.

Gene Pathways:

  • Disease
  • Signal Transduction

Caution:

It is uncertain whether Met-1 or Met-8 is the initiator.

Molecular Function:

  • Chromatin Binding
  • Transcription Corepressor Activity
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding

Biological Processes:

  • Beta-Catenin-Tcf Complex Assembly
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Transcription, Dna-Templated
  • Wnt Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| XTCF-4| ESG| transducin-like enhancer of split 4| tle1| AS27_02922| AS28_10954| BCE1| BCE-1| B lymphocyte gene 1| CB1_001144005| enhancer of split groucho 4| ESG4| Esp2| E(spI)| ESTM13| ESTM14| grg-4| Grg4| gro| groucho-related gene 4| groucho-related protein 4| M959_07706| MDA_GLEAN10017433| N300_09228| N301_09475| N303_05267| N306_13330| N309_00390| N311_03088| N312_12651| N321_01682| N322_05646| N324_02630| N326_01548| N327_00673| N329_06618| N335_05383| N336_05193| PAL_GLEAN10021121| transducin-like enhancer of split 4 (E(sp1) homolog)| transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)| transducin-like enhancer of split 4, E(spl) homolog| transducin-like enhancer of split 4, homolog of Drosophila E(sp1)| transducin-like enhancer of split 4 homolog of Drosophila E(spl)| transducin-like enhancer of split 4, homolog of Drosophila E(spl)| Transducin-like enhancer protein 4| UY3_12412| X83332| X83333| Xgrg4| XGrg-4| X-groucho| Xtle4| Y1Q_027468| Z169_00159| tle4

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