The Function of TLE4
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression.
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Protein names
Recommended name:
Transducin-like enhancer protein 4Alternative name(s):
Grg-4Groucho-related protein 4
- RS13292136 (TLE4) ??
- RS13293121 (TLE4) ??
- RS17791483 (TLE4) ??
- RS17791513 (TLE4) ??
- RS914715 (TLE4) ??
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Top Gene-Substance Interactions
TLE4 Interacts with These Diseases
| Disease | Score |
Substances That Increase TLE4
| Substances | Interaction | Organism | Category |
Substances That Decrease TLE4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
In all tissues examined, mostly in brain, and muscle.
Gene Pathways:
Caution:
It is uncertain whether Met-1 or Met-8 is the initiator.
Molecular Function:
- Chromatin Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcription Corepressor Activity
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Transcription, Dna-Templated
- Wnt Signaling Pathway
- Beta-Catenin-Tcf Complex Assembly