The Function of TLE3
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.
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Protein names
Recommended name:
Transducin-like enhancer protein 3Short name:
ESG3Alternative name(s):
Enhancer of split groucho-like protein 3- RS11630316 (TLE3) ??
- RS1971791 (TLE3) ??
- RS315122 (TLE3) ??
- RS6494849 (TLE3) ??
- RS884483 (TLE3) ??
- RS975210 (TLE3) ??
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Top Gene-Substance Interactions
TLE3 Interacts with These Diseases
| Disease | Score |
Substances That Increase TLE3
| Substances | Interaction | Organism | Category |
Substances That Decrease TLE3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Placenta and lung.
Gene Pathways:
Biological Processes:
- Transcription, Dna-Templated
- Regulation Of Transcription, Dna-Templated
- Signal Transduction
- Animal Organ Morphogenesis
- Wnt Signaling Pathway
- Beta-Catenin-Tcf Complex Assembly