The Function of TLE1
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
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Protein names
Recommended name:
Transducin-like enhancer protein 1Short name:
ESG1Alternative name(s):
E(Sp1Enhancer of split groucho-like protein 1
- RS2777777 (TLE1) ??
- RS815847 (TLE1) ??
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Top Gene-Substance Interactions
Substances That Increase TLE1
| Substances | Interaction | Organism | Category |
Substances That Decrease TLE1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
In all tissues examined, mostly in brain, liver and muscle.
Molecular Function:
- Identical Protein Binding
- Rna Polymerase Ii Transcription Corepressor Activity
- Transcription Factor Binding
Biological Processes:
- Animal Organ Morphogenesis
- Beta-Catenin-Tcf Complex Assembly
- Multicellular Organism Development
- Negative Regulation Of Anoikis
- Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Wnt Signaling Pathway
- Positive Regulation Of Gene Expression
- Signal Transduction
- Transcription, Dna-Templated
- Wnt Signaling Pathway