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  3. TLE1

TLE1 (Transducin like enhancer of split 1)

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The Function of TLE1

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

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Protein names

Recommended name:

Transducin-like enhancer protein 1

Short name:

ESG1

Alternative name(s):

E(Sp1
Enhancer of split groucho-like protein 1

TLE1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2777777 (TLE1) ??
  2. RS815847 (TLE1) ??

Top Gene-Substance Interactions

Substances That Increase TLE1

Substances Interaction Organism Category

Substances That Decrease TLE1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • NF-kappaB1

Tissue specificity:

In all tissues examined, mostly in brain, liver and muscle.

Molecular Function:

  • Identical Protein Binding
  • Rna Polymerase Ii Transcription Corepressor Activity
  • Transcription Factor Binding

Biological Processes:

  • Animal Organ Morphogenesis
  • Beta-Catenin-Tcf Complex Assembly
  • Multicellular Organism Development
  • Negative Regulation Of Anoikis
  • Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Negative Regulation Of Transcription, Dna-Templated
  • Negative Regulation Of Wnt Signaling Pathway
  • Positive Regulation Of Gene Expression
  • Signal Transduction
  • Transcription, Dna-Templated
  • Wnt Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_04381| AS27_02919| AS28_10955| enhancer of split groucho-like protein 1| ESG| ESG1| Estm14| Grg-1| GRG1| groucho-related protein 1| GW7_04580| I79_006375| M959_11250| MDA_GLEAN10017438| N300_09229| N301_10281| N303_05266| N305_03701| N306_13554| N307_02277| N308_03749| N309_08548| N310_11313| N311_10516| N312_11809| N320_09731| N321_01372| N322_08294| N324_00343| N325_12808| N328_02802| N331_02785| N333_06222| N334_13005| N335_12065| N336_00745| N339_03277| N340_00463| PAL_GLEAN10002580| TLE4| Tle4l| transducin-like enhancer of split 1| transducin-like enhancer of split 1 (E(sp1) homolog)| transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)| transducin-like enhancer of split 1 (E(sp1)-like)| transducin-like enhancer of split 1, homolog of Drosophila E(spl)| transducin-like enhancer of split 4| transducin-like enhancer of split 4 (homolog of Drosophila E(spl)) - like| Transducin-like enhancer protein 1| TREES_T100013043| UY3_12410| xgrg1| Y1Q_003833| Y956_09933| Z169_14834| tle1

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